Kdm5a Phenotype Annotations - Multigenic Genotypes

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Kdm5a
lysine demethylase 5A
MGI:2136980

11 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Kdm5a^tm1.1Kael/Kdm5a⁺ Rb1^tm1Tyj/Rb1⁺ involves: 129S2/SvPas * 129S6/SvEvTac * FVB/N	increased pituitary gland tumor incidence	J:175625
	increased thyroid tumor incidence	J:175625
Kdm5a^tm1.1Kael/Kdm5a⁺ Rb1^tm1Tyj/Rb1^tm1Tyj involves: 129S2/SvPas * 129S6/SvEvTac * FVB/N	embryonic lethality, complete penetrance	J:175625
	increased fibroblast proliferation	J:175625
Kdm5a^tm1.1Kael/Kdm5a^tm1.1Kael Rb1^tm1Tyj/Rb1⁺ involves: 129S2/SvPas * 129S6/SvEvTac * FVB/N	increased pituitary gland tumor incidence	J:175625
	increased thyroid tumor incidence	J:175625
	premature death	J:175625
Kdm5a^tm1.1Kael/Kdm5a^tm1.1Kael Rb1^tm1Tyj/Rb1^tm1Tyj involves: 129S2/SvPas * 129S6/SvEvTac * FVB/N	abnormal cell differentiation	J:175625
	normal cellular phenotype	J:175625
	embryonic lethality, complete penetrance	J:175625
Kdm5a^tm1Kael/Kdm5a^tm1Kael Men1^tm2.1Mmey/Men1^tm2.1Mmey Tg(Ins2-cre)23Herr/0 involves: 129S6/SvEvTac * C57BL/6 * CBA/J * FVB/N	abnormal pancreatic islet morphology	J:175625
	normal endocrine/exocrine gland phenotype	J:175625
	increased insulinoma incidence	J:175625
	pancreatic islet hyperplasia	J:175625
	premature death	J:175625

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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