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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pik3ap1
phosphoinositide-3-kinase adaptor protein 1
MGI:1933177
22 phenotypes from 5 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Pik3ap1m1Btlr/Pik3ap1m1Btlr
involves: C57BL/6J 		arrested B cell differentiation J:185495
decreased IgM level J:185495
normal immune system phenotype J:185495
Pik3ap1m2Btlr/Pik3ap1m2Btlr
C57BL/6J-Pik3ap1m2Btlr 		decreased B-1a cell number J:255271
impaired humoral immune response J:255271
increased B-1b cell number J:255271
increased IgM level J:255271
Pik3ap1M3Btlr/Pik3ap1M3Btlr
C57BL/6J-Pik3ap1M3Btlr 		decreased B-1 B cell number J:272019
Pik3ap1tm1b(KOMP)Wtsi/Pik3ap1tm1b(KOMP)Wtsi
C57BL/6N-Pik3ap1tm1b(KOMP)Wtsi/Orl 		abnormal cholesterol homeostasis J:211773
decreased lymphocyte cell number J:211773
increased monocyte cell number J:211773
increased neutrophil cell number J:211773
Pik3ap1tm1Kuro/Pik3ap1tm1Kuro
involves: 129P2/OlaHsd 		abnormal B cell differentiation J:75075
absent B-1a cells J:84669
decreased B cell number J:84669
decreased B cell proliferation J:84669
decreased follicular B cell number J:84669
decreased IgG2b level J:75075
decreased IgG3 level J:75075
decreased IgM level J:75075
decreased immunoglobulin level J:75075
decreased pre-B cell number J:75075
spleen hypoplasia J:75075
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory