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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Rnf8
ring finger protein 8
MGI:1929069
43 phenotypes from 2 alleles in 1 genetic background
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Allelic Composition
Genetic Background		 Annotated Term Reference
Rnf8Gt(AS0574)Wtsi/Rnf8+
involves: 129P2/OlaHsd * C57BL/6 		abnormal class switch recombination J:161240
decreased body size J:161240
increased cellular sensitivity to gamma-irradiation J:161240
normal neoplasm J:161240
premature death J:161240
Rnf8Gt(AS0574)Wtsi/Rnf8Gt(AS0574)Wtsi
involves: 129P2/OlaHsd * C57BL/6 		abnormal class switch recombination J:161240
abnormal seminiferous tubule epithelium morphology J:161240
abnormal spermatocyte morphology J:161240
abnormal spermatogenesis J:161240
abnormal spermatogonia morphology J:161240
azoospermia J:161240
decreased B cell number J:161240
decreased body size J:161240
decreased body weight J:161240
decreased bone marrow cell number J:161240
decreased CD4-positive, alpha-beta T cell number J:161240
decreased CD8-positive, alpha-beta T cell number J:161240
decreased double-negative T cell number J:161240
decreased double-positive T cell number J:161240
decreased fibroblast proliferation J:161240
decreased IgG1 level J:161240
decreased IgG2b level J:161240
decreased IgG3 level J:161240
decreased immature B cell number J:161240
decreased litter size J:161240
decreased pre-B cell number J:161240
decreased pro-B cell number J:161240
decreased splenocyte number J:161240
decreased T cell number J:161240
decreased thymocyte number J:161240
increased cellular sensitivity to gamma-irradiation J:161240
increased lymphoma incidence J:161240
increased mammary adenocarcinoma incidence J:161240
increased mortality induced by gamma-irradiation J:161240
increased sarcoma incidence J:161240
increased skin tumor incidence J:161240
increased T cell derived lymphoma incidence J:161240
increased thymocyte apoptosis J:161240
induced chromosome breakage J:161240
oligozoospermia J:161240
postnatal growth retardation J:161240
premature death J:161240
reduced male fertility J:161240
seminiferous tubule degeneration J:161240
small testis J:161240
spontaneous chromosome breakage J:161240
Rnf8Gt(RRR260)Byg/Rnf8Gt(RRR260)Byg
involves: 129P2/OlaHsd * C57BL/6 		abnormal class switch recombination J:161240
abnormal seminiferous tubule epithelium morphology J:161240
abnormal spermatocyte morphology J:161240
abnormal spermatogenesis J:161240
abnormal spermatogonia morphology J:161240
azoospermia J:161240
decreased B cell number J:161240
decreased body size J:161240
decreased body weight J:161240
decreased bone marrow cell number J:161240
decreased CD4-positive, alpha-beta T cell number J:161240
decreased CD8-positive, alpha-beta T cell number J:161240
decreased double-negative T cell number J:161240
decreased double-positive T cell number J:161240
decreased fibroblast proliferation J:161240
decreased IgG1 level J:161240
decreased IgG2b level J:161240
decreased IgG3 level J:161240
decreased immature B cell number J:161240
decreased pre-B cell number J:161240
decreased pro-B cell number J:161240
decreased splenocyte number J:161240
decreased T cell number J:161240
decreased thymocyte number J:161240
increased cellular sensitivity to gamma-irradiation J:161240
increased lymphoma incidence J:161240
increased mammary adenocarcinoma incidence J:161240
increased mortality induced by gamma-irradiation J:161240
increased sarcoma incidence J:161240
increased skin tumor incidence J:161240
increased T cell derived lymphoma incidence J:161240
increased thymocyte apoptosis J:161240
induced chromosome breakage J:161240
male infertility J:161240
oligozoospermia J:161240
postnatal growth retardation J:161240
premature death J:161240
seminiferous tubule degeneration J:161240
small testis J:161240
spontaneous chromosome breakage J:161240
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory