Slc25a12 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Slc25a12
solute carrier family 25 (mitochondrial carrier, Aralar), member 12
MGI:1926080

32 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Slc25a12^{em1(IMPC)Hmgu}/Slc25a12^{em1(IMPC)Hmgu} C57BL/6N-Slc25a12^{em1(IMPC)Hmgu}/Ieg	preweaning lethality, complete penetrance	J:211773
Slc25a12^{Gt(OST123999)Lex}/Slc25a12⁺ involves: 129S5/SvEvBrd * C57BL/6	abnormal nervous system physiology	J:193095
	enhanced behavioral response to amphetamine	J:193095
Slc25a12^{Gt(OST123999)Lex}/Slc25a12^{Gt(OST123999)Lex} involves: 129S5/SvEvBrd * C57BL/6	abnormal aerobic respiration	J:101164
	abnormal brain morphology	J:101164, J:193095, J:243212
	abnormal cellular respiration	J:243212
	abnormal dopamine level	J:193095
	abnormal GABAergic neuron morphology	J:193095
	abnormal gait	J:193095
	abnormal myelination	J:101164
	abnormal nervous system physiology	J:193095
	abnormal synaptic dopamine release	J:193095
	convulsive seizures	J:101164
	decreased body weight	J:101164
	decreased gamma-aminobutyric acid level	J:193095
	decreased serotonin level	J:193095
	decreased striatum size	J:193095
	enlarged lateral ventricles	J:101164, J:193095
	hunched posture	J:101164
	hyperresponsive	J:193095
	impaired balance	J:193095
	impaired coordination	J:101164
	impaired limb coordination	J:193095
	increased anxiety-related response	J:193095
	increased locomotor activity	J:193095
	increased taurine level	J:243212
	increased thigmotaxis	J:193095
	increased vertical activity	J:193095
	limb grasping	J:193095
	oxidative stress	J:193095
	postnatal growth retardation	J:101164
	postnatal lethality, complete penetrance	J:101164, J:243212
	tremors	J:101164

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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