Hectd3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Hectd3
HECT domain E3 ubiquitin protein ligase 3
MGI:1923858

22 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Hectd3^{tm1(NCOM)Cmhd}/Hectd3^{tm1(NCOM)Cmhd} C57BL/6N-Hectd3^{tm1(NCOM)Cmhd}/Nju	abnormal bone structure	J:211773
	decreased body length	J:211773
	decreased bone mineral content	J:211773
	decreased bone mineral density	J:211773
	decreased brain size	J:211773
	decreased grip strength	J:211773
	female infertility	J:211773
	increased cardiac muscle contractility	J:211773
	increased total body fat amount	J:211773
	male infertility	J:211773
	small heart	J:211773
	small liver	J:211773
	small lung	J:211773
	small spleen	J:211773
	small stomach	J:211773
	small thymus	J:211773
Hectd3^tm1Lex/Hectd3^tm1Lex FVB.129S5(B6)-Hectd3^tm1Lex	decreased circulating interferon-beta level	J:266602
	decreased circulating interleukin-1 beta level	J:266602
	decreased circulating interleukin-6 level	J:266602
	decreased circulating tumor necrosis factor level	J:266602
	decreased susceptibility to bacterial infection	J:266602
	decreased susceptibility to bacterial infection induced morbidity/mortality	J:266602

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23