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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Knl1
kinetochore scaffold 1
MGI:1923714
20 phenotypes from 4 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Knl1m1Anu/Knl1m1Anu
C57BL/6NCrlAnu-Knl1m1Anu
embryonic lethality J:104190
Knl1Tg(Tyr)2397HOve/Knl1Tg(Tyr)2397HOve
FVB/N-Knl1Tg(Tyr)2397HOve
embryonic lethality between implantation and somite formation, complete penetrance J:175597
Knl1tm1b(EUCOMM)Hmgu/Knl1+
C57BL/6N-Knl1tm1b(EUCOMM)Hmgu/Ieg
abnormal lens morphology J:211773
cataract J:211773
impaired glucose tolerance J:211773
Knl1tm1b(EUCOMM)Hmgu/Knl1tm1b(EUCOMM)Hmgu
C57BL/6N-Knl1tm1b(EUCOMM)Hmgu/Ieg
preweaning lethality, complete penetrance J:211773
Knl1tm1c(EUCOMM)Hmgu/Knl1tm1c(EUCOMM)Hmgu
Emx1tm1(cre)Krj/Emx1+
involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6N
decreased neuron number J:278483
microcephaly J:278483
telencephalon hypoplasia J:278483
Knl1tm1c(EUCOMM)Hmgu/Knl1tm1c(EUCOMM)Hmgu
Tg(GFAP-cre)25Mes/0
involves: 129S4/SvJaeSor * C57BL/6N * FVB/N
abnormal double-strand DNA break repair J:278483
abnormal mitotic cytokinesis J:278483
absent corpus callosum J:278483
decreased body size J:278483
decreased neuron number J:278483
decreased neuronal precursor cell number J:278483
decreased survivor rate J:278483
increased apoptosis J:278483
microcephaly J:278483
microgliosis J:278483
postnatal lethality, incomplete penetrance J:278483
premature neuronal precursor differentiation J:278483
telencephalon hypoplasia J:278483
thin cortical plate J:278483

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory