Irak3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Irak3
interleukin-1 receptor-associated kinase 3
MGI:1921164

29 phenotypes from 1 allele in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Irak3^tm1Flv/Irak3^tm1Flv involves: 129S1/Sv * C57BL/6	abnormal compact bone morphology	J:98035
	abnormal immune system morphology	J:78189
	abnormal inflammatory response	J:78189
	abnormal innate immunity	J:78189
	abnormal osteoclast physiology	J:98035
	abnormal Peyer's patch morphology	J:78189
	abnormal trabecular bone morphology	J:98035
	decreased body size	J:98035
	decreased compact bone thickness	J:98035
	decreased diameter of femur	J:98035
	decreased trabecular bone volume	J:98035
	enlarged Peyer's patches	J:78189
	increased interleukin-6 secretion	J:78189
	increased interleukin-12b secretion	J:78189
	increased neutrophil cell number	J:78189
	increased osteoblast cell number	J:98035
	increased osteoclast cell number	J:98035
	increased susceptibility to endotoxin shock	J:78189
	increased tumor necrosis factor secretion	J:78189
	kyphosis	J:98035
Irak3^tm1Flv/Irak3^tm1Flv NOD.129S1(B6)-Irak3^tm1Flv	abnormal dendritic cell physiology	J:229884
	abnormal professional antigen presenting cell physiology	J:229884
	abnormal T cell activation	J:229884
	abnormal T cell differentiation	J:229884
	impaired glucose tolerance	J:229884
	increased anti-insulin autoantibody level	J:229884
	increased effector memory T-helper cell number	J:229884
	increased susceptibility to autoimmune diabetes	J:229884
	insulitis	J:229884

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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