Thoc1 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Thoc1
THO complex 1
MGI:1919668

17 phenotypes from 4 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Meox2^tm1(cre)Sor/Meox2⁺ Thoc1^tm2.1Dwg/Thoc1^tm2.1Dwg involves: 129S4/SvJae * C57BL/6J	abnormal embryonic tissue morphology	J:117869
	embryonic lethality before implantation, complete penetrance	J:117869
Thoc1^{em1(IMPC)Ccpcz}/Thoc1⁺ C57BL/6NCrl-Thoc1^{em1(IMPC)Ccpcz}/Ccpcz	abnormal digit morphology	J:211773
	decreased lean body mass	J:211773
	increased mean corpuscular hemoglobin	J:211773
	increased mean corpuscular volume	J:211773
	increased mean platelet volume	J:211773
	increased total body fat amount	J:211773
Thoc1^{em1(IMPC)Ccpcz}/Thoc1^{em1(IMPC)Ccpcz} C57BL/6NCrl-Thoc1^{em1(IMPC)Ccpcz}/Ccpcz	preweaning lethality, complete penetrance	J:211773
Thoc1^tm1Dwg/Thoc1^tm1Dwg involves: 129S4/SvJae	absent inner cell mass	J:109614
	embryonic lethality at implantation, complete penetrance	J:109614
	failure of blastocyst to hatch from the zona pellucida	J:109614
	increased embryonic tissue cell apoptosis	J:109614
Thoc1^tm1Dwg/Thoc1^tm2Dwg involves: 129S4/SvJae * C57BL/6J	decreased embryo size	J:117869
Thoc1^tm1Dwg/Thoc1^tm2Dwg involves: 129S4/SvJae * C57BL/6J	lethality throughout fetal growth and development, complete penetrance	J:117869
Thoc1^tm2Dwg/Thoc1^tm2Dwg involves: 129S4/SvJae * C57BL/6J	decreased body size	J:117869
	decreased body weight	J:117869
	decreased embryo size	J:117869

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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