Optn Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Optn
optineurin
MGI:1918898

21 phenotypes from 3 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Optn^em1Hyua/Optn⁺ C57BL/6J-Optn^em1Hyua	impaired coordination	J:303304
Optn^em1Hyua/Optn^em1Hyua C57BL/6J-Optn^em1Hyua	abnormal axonal transport	J:324291
	abnormal behavioral response to light	J:303304
	abnormal eye physiology	J:324291
	abnormal vision	J:303304, J:324291
	abnormal visual evoked potential	J:303304, J:324291
	axon degeneration	J:324291
	decreased total retina thickness	J:324291
	impaired autophagy	J:303304
	increased retina apoptosis	J:303304
	retina ganglion cell degeneration	J:324291
	thin retina ganglion layer	J:303304, J:324291
	vision/eye phenotype	J:303304
Optn^tm1.2Jda/Optn^tm1.2Jda B6.Cg-Optn^tm1.2Jda	normal immune system phenotype	J:207113
Optn^tm1.2Jda/Optn^tm1.2Jda B6.Cg-Optn^tm1.2Jda	normal mortality/aging	J:207113
Optn^tm1.2Jda/Optn^tm1.2Jda involves: 129S4/SvJae * C57BL/6J	embryonic lethality, incomplete penetrance	J:207113
	normal immune system phenotype	J:207113
Optn^{tm1a(EUCOMM)Wtsi}/Optn⁺ C57BL/6N-Optn^{tm1a(EUCOMM)Wtsi}/Ieg	abnormal respiratory quotient	J:165965
Optn^{tm1a(EUCOMM)Wtsi}/Optn^{tm1a(EUCOMM)Wtsi} C57BL/6N-Optn^{tm1a(EUCOMM)Wtsi}/Wtsi	decreased circulating cholesterol level	J:175295
	decreased circulating HDL cholesterol level	J:175295
	decreased circulating LDL cholesterol level	J:175295
	decreased circulating potassium level	J:175295

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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