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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Prdm16
PR domain containing 16
MGI:1917923
69 phenotypes from 3 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Prdm16csp1/Prdm16+
FVB.C-Prdm16csp1
cleft secondary palate J:157112
Prdm16csp1/Prdm16csp1
FVB.C-Prdm16csp1
abnormal choroid plexus morphology J:157112
abnormal heart morphology J:157112
abnormal heart ventricle morphology J:157112
abnormal lung morphology J:157112
abnormal mandible morphology J:157112
abnormal nasal bone morphology J:157112
abnormal palatal shelf elevation J:157112
abnormal retina morphology J:157112
abnormal snout morphology J:157112
abnormal sublingual duct morphology J:157112
abnormal sublingual gland morphology J:157112
abnormal submandibular duct morphology J:157112
abnormal tongue morphology J:157112
cleft secondary palate J:157112
distended abdomen J:157112
mandible hypoplasia J:157112
micrognathia J:157112
narrow maxilla J:157112
narrow snout J:157112
neonatal lethality, complete penetrance J:157112
premature bone ossification J:157112
pulmonary hypoplasia J:157112
respiratory distress J:157112
respiratory failure J:157112
short maxilla J:157112
short Meckel's cartilage J:157112
short nasal bone J:157112
short snout J:157112
small lung J:157112
small mandible J:157112
submandibular gland hypoplasia J:157112
ventricular hypoplasia J:157112
Prdm16csp1/Prdm16csp1
involves: BALB/c * C57BL/6J * FVB/NJ
cleft secondary palate J:157112
neonatal lethality, complete penetrance J:157112
respiratory failure J:157112
submucous cleft palate J:157112
Prdm16csp1/Prdm16csp1
Not Specified
cleft secondary palate J:75360
Prdm16csp1/Prdm16Gt(OST67423)Lex
involves: 129S5/SvEvBrd * BALB/c * C57BL/6J * FVB/NJ
cleft secondary palate J:157112
Prdm16Gt(OST67423)Lex/Prdm16+
involves: 129S5/SvEvBrd * C57BL/6J
increased leukocyte cell number J:103485
Prdm16Gt(OST67423)Lex/Prdm16Gt(OST67423)Lex
involves: 129S5/SvEvBrd * C57BL/6J
abnormal heart morphology J:157112
abnormal tongue morphology J:157112
cleft secondary palate J:157112
perinatal lethality, complete penetrance J:103485
pointed snout J:157112
prenatal lethality, incomplete penetrance J:103485
ventricular hypoplasia J:157112
Prdm16tm1.1Brsp/Prdm16tm1.1Brsp
B6.129-Prdm16tm1.1Brsp
no abnormal phenotype detected J:208683
Prdm16tm1.1Brsp/Prdm16tm1.1Brsp
Myf5tm1(cre)Mrc/Myf5+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal brown adipose tissue morphology J:213153
abnormal brown adipose tissue thermogenesis J:213153
abnormal cellular respiration J:213153
abnormal interscapular fat pad morphology J:213153
abnormal oxygen consumption J:213153
decreased body fat mass J:213153
decreased body length J:213153
decreased body weight J:213153
decreased brown fat lipid droplet number J:213153
decreased lean body mass J:213153
decreased mitochondria number J:213153
decreased mitochondrial DNA content J:213153
impaired adaptive thermogenesis J:213153
improved glucose tolerance J:213153
increased brown fat cell lipid droplet size J:213153
increased interscapular fat pad weight J:213153
whitened brown adipose tissue morphology J:213153
Prdm16tm1.1Brsp/Prdm16tm1.1Brsp
Tg(Adipoq-cre)1Evdr/0
involves: 129/Sv * C57BL/6 * FVB/N
abnormal adipose tissue distribution J:208683
abnormal adipose tissue morphology J:208683
abnormal adipose tissue physiology J:208683
abnormal brown adipose tissue thermogenesis J:208683
abnormal oxygen consumption J:208683
decreased adipocyte glucose uptake J:208683
hepatic steatosis J:208683
increased circulating insulin level J:208683
increased fat cell size J:208683
increased liver triglyceride level J:208683
increased macrophage cell number J:208683
increased respiratory quotient J:208683
increased subcutaneous adipose tissue amount J:208683
increased susceptibility to weight gain J:208683
increased total body fat amount J:208683
insulin resistance J:208683

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/11/2019
MGI 6.14
The Jackson Laboratory