Cox10 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cox10
heme A:farnesyltransferase cytochrome c oxidase assembly factor 10
MGI:1917633

32 phenotypes from 1 allele in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cox10^tm1Ctm/Cox10^tm1Ctm Myl1^tm1(cre)Sjb/Myl1⁺ involves: 129X1/SvJ * C57BL/6	abnormal skeletal muscle morphology	J:101747
	decreased locomotor activity	J:101747
	decreased skeletal muscle mass	J:101747
	increased muscle fatigability	J:101747
	increased variability of skeletal muscle fiber size	J:101747
	kyphosis	J:101747
	myopathy	J:101747
	premature death	J:101747
	weight loss	J:101747
Cox10^tm1Ctm/Cox10^tm1Ctm Slc6a3^{tm1.1(cre)Bkmn}/? B6.Cg-Cox10^tm1Ctm Slc6a3^{tm1.1(cre)Bkmn}	abnormal chemokine secretion	J:231810
	abnormal motor capabilities/coordination/movement	J:231810
	decreased body weight	J:231810
	decreased dopamine level	J:231810
	decreased dopaminergic neuron number	J:231810
	decreased locomotor activity	J:231810
	decreased vertical activity	J:231810
	impaired coordination	J:231810
	increased interleukin-1 beta secretion	J:231810
	increased microglial cell activation	J:231810
	loss of dopaminergic neurons	J:231810
	microgliosis	J:231810
Cox10^tm1Ctm/Cox10^tm1Ctm Tg(Camk2a-cre)#Szi/0 involves: 129X1/SvJ * C57BL/6 * C57BL/6J * CBA	abnormal cerebral cortex morphology	J:188773
	abnormal cingulate gyrus morphology	J:188773
	abnormal enzyme/coenzyme activity	J:188773
	abnormal glial cell physiology	J:188773
	abnormal locomotor activation	J:188773
	abnormal mitochondrial physiology	J:188773
	abnormal nervous system physiology	J:188773
	abnormal piriform cortex morphology	J:188773
	decreased body weight	J:188773
	decreased brain weight	J:188773
	hippocampal neuron degeneration	J:188773
	impaired coordination	J:188773
	neurodegeneration	J:188773
	neuron degeneration	J:188773
	premature death	J:188773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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