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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ace2
angiotensin converting enzyme 2
MGI:1917258
82 phenotypes from 11 alleles in 17 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ace2em1(ACE2)Yowa/Ace2em1(ACE2)Yowa
C57BL/6-Ace2em1(ACE2)Yowa 		abnormal circulating cytokine level J:288243
abnormal pulmonary alveolus epithelial cell morphology J:288243
increased circulating interferon-gamma level J:288243
increased circulating interleukin-9 level J:288243
increased susceptibility to Coronaviridae infection J:288243
interstitial pneumonia J:288243
lung hemorrhage J:288243
thick pulmonary interalveolar septum J:288243
Ace2em1(IMPC)Ccpcz/Y
C57BL/6NCrl-Ace2em1(IMPC)Ccpcz/Ccpcz 		abnormal heart morphology J:211773
abnormal spleen morphology J:211773
enlarged heart J:211773
enlarged spleen J:211773
Ace2em1(IMPC)Ccpcz/Ace2em1(IMPC)Ccpcz
C57BL/6NCrl-Ace2em1(IMPC)Ccpcz/Ccpcz 		abnormal retina morphology J:211773
abnormal spleen morphology J:211773
abnormal thymus morphology J:211773
abnormal uterus morphology J:211773
decreased lean body mass J:211773
enlarged spleen J:211773
enlarged thymus J:211773
hydrometra J:211773
increased total body fat amount J:211773
Ace2em1Cya/Y
C57BL/6J-Ace2em1Cya/Cya 		abnormal feces composition J:299383
abnormal intestine morphology J:299383
abnormal intestine physiology J:299383
decreased colon length J:299383
impaired intestine regeneration J:299383
increased susceptibility to induced colitis J:299383
increased susceptibility to weight loss J:299383
intestinal edema J:299383
intestinal inflammation J:299383
melena J:299383
oxidative stress J:299383
Ace2em1Shyy/Ace2em1Shyy
B6.Cg-Ace2em1Shyy 		pulmonary hypertension J:286356
Ace2em2Shyy/Ace2em2Shyy
B6.Cg-Ace2em2Shyy 		decreased pulmonary artery pressure J:286356
Ace2em#Yngh/Y
involves: Kunming 		decreased colon length J:221616
diarrhea J:221616
increased susceptibility to induced colitis J:221616
increased susceptibility to weight loss J:221616
Ace2tm1a(KOMP)Wtsi/Ace2tm1a(KOMP)Wtsi
Tg(FOXJ1-cre)F26Htzm/0
involves: C57BL/6N * C57BL/6NTac 		increased neutrophil cell number J:282139
increased susceptibility to bacterial infection J:282139
increased susceptibility to bacterial infection induced morbidity/mortality J:282139
increased susceptibility to weight loss J:282139
lung inflammation J:282139
Ace2tm1a(KOMP)Wtsi/Y
Tg(FOXJ1-cre)F26Htzm/0
involves: C57BL/6N * C57BL/6NTac 		increased neutrophil cell number J:282139
increased susceptibility to bacterial infection J:282139
increased susceptibility to bacterial infection induced morbidity/mortality J:282139
increased susceptibility to weight loss J:282139
lung inflammation J:282139
Ace2tm1Cof/Y
129S6/SvEvTac-Ace2tm1Cof 		normal cardiovascular system phenotype J:113108
hypertension J:113108
increased angiotensin II level J:113108
increased circulating angiotensin II level J:113108
Ace2tm1Cof/Y
B6.129S6-Ace2tm1Cof 		increased systemic arterial systolic blood pressure J:113108
Ace2tm1Cof/Y
involves: 129S6/SvEvTac * C57BL/6J 		decreased heart rate J:113108
increased systemic arterial systolic blood pressure J:113108
Ace2tm1Cof/Ace2tm1Cof
involves: 129S6/SvEvTac * C57BL/6 		abnormal corneal epithelium morphology J:289503
abnormal corneal wound healing J:289503
corneal opacity J:289503
corneal vascularization J:289503
increased incidence of corneal inflammation J:289503
Ace2tm1Hira/Y
involves: 129S7/SvEvBrd * C57BL/6 		cardiac fibrosis J:135766
cardiac interstitial fibrosis J:135766
congestive heart failure J:135766
decreased ventricle muscle contractility J:135766
dilated heart left ventricle J:135766
increased angiotensin II level J:135766
increased circulating angiotensin II level J:135766
increased heart weight J:135766
increased lung weight J:135766
increased susceptibility to induced morbidity/mortality J:135766
pulmonary vascular congestion J:135766
Ace2tm1Lex/Y
B6;129S5-Ace2tm1Lex/Mmucd 		yellow coat color J:171883
Ace2tm1Lex/Ace2tm1Lex
B6;129S5-Ace2tm1Lex/Mmucd 		abnormal enzyme/coenzyme activity J:264991
increased angiotensin I-converting enzyme activity J:264991
increased pulmonary respiratory rate J:264991
lung inflammation J:264991
yellow coat color J:171883
Ace2tm1Pngr/Y
B6.129P2-Ace2tm1Pngr/J 		normal cardiovascular system phenotype J:124548
decreased susceptibility to Coronaviridae infection J:286299
Ace2tm1Pngr/Y
involves: 129P2/OlaHsd 		abnormal susceptibility to injury induced morbidity/mortality J:100334
increased angiotensin II level J:100334
increased circulating angiotensin II level J:100334
increased lung elastance J:100334
increased neutrophil cell number J:282139
increased susceptibility to bacterial infection J:282139
increased susceptibility to bacterial infection induced morbidity/mortality J:282139
increased susceptibility to injury J:100334
increased susceptibility to pulmonary hyaline membrane formation J:100334
increased susceptibility to weight loss J:282139
increased vascular permeability J:100334
lung inflammation J:100334, J:282139
pulmonary edema J:100334
Ace2tm1Pngr/Y
involves: 129P2/OlaHsd * C57BL/6 		abnormal cardiovascular system physiology J:124548
abnormal cytokine level J:124548
abnormal heart echocardiography feature J:124548
cardiac hypertrophy J:124548
congestive heart failure J:124548
decreased cardiac muscle contractility J:77232, J:124548
decreased heart left ventricle wall thickness J:77232
dilated cardiomyopathy J:124548
dilated heart left ventricle J:124548
dilated heart ventricle J:124548
heart inflammation J:124548
hypotension J:77232
increased left ventricle diastolic pressure J:124548
increased NAD(P)H oxidase activity J:124548
oxidative stress J:124548
Ace2tm1Pngr/Y
involves: 129P2/OlaHsd * C57BL/6J 		increased susceptibility to Orthomyxoviridae infection J:277074
increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality J:277074
increased susceptibility to pulmonary hyaline membrane formation J:277074
lung inflammation J:277074
pulmonary edema J:277074
Ace2tm1Pngr/Ace2tm1Pngr
B6.129P2-Ace2tm1Pngr/J 		decreased susceptibility to Coronaviridae infection J:286299
Ace2tm1Pngr/Ace2tm1Pngr
involves: 129P2/OlaHsd 		abnormal susceptibility to injury induced morbidity/mortality J:100334
increased angiotensin II level J:100334
increased circulating angiotensin II level J:100334
increased lung elastance J:100334
increased neutrophil cell number J:282139
increased susceptibility to bacterial infection J:282139
increased susceptibility to bacterial infection induced morbidity/mortality J:282139
increased susceptibility to injury J:100334
increased susceptibility to pulmonary hyaline membrane formation J:100334
increased susceptibility to weight loss J:282139
increased vascular permeability J:100334
lung inflammation J:100334, J:282139
pulmonary edema J:100334
Ace2tm1Pngr/Ace2tm1Pngr
involves: 129P2/OlaHsd * C57BL/6 		decreased cardiac muscle contractility J:77232
Ace2tm1Pngr/Ace2tm1Pngr
involves: 129P2/OlaHsd * C57BL/6J 		increased susceptibility to Orthomyxoviridae infection J:277074
increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality J:277074
increased susceptibility to pulmonary hyaline membrane formation J:277074
lung inflammation J:277074
pulmonary edema J:277074
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/16/2024
MGI 6.23 		The Jackson Laboratory