Smpdl3b Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Smpdl3b
sphingomyelin phosphodiesterase, acid-like 3B
MGI:1916022

9 phenotypes from 1 allele in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Smpdl3b^{tm1a(EUCOMM)Wtsi}/Smpdl3b^{tm1a(EUCOMM)Wtsi} C57BL/6-Smpdl3b^{tm1a(EUCOMM)Wtsi}	abnormal chemokine secretion	J:224870
	abnormal circulating chemokine level	J:224870
	abnormal macrophage morphology	J:224870
	increased circulating interleukin-6 level	J:224870
	increased circulating interleukin-12b level	J:224870
	increased circulating tumor necrosis factor level	J:224870
	increased neutrophil cell number	J:224870
	increased susceptibility to endotoxin shock	J:224870
Smpdl3b^{tm1a(EUCOMM)Wtsi}/Smpdl3b^{tm1a(EUCOMM)Wtsi} Not Specified	decreased locomotor activity	J:165965

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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