Atg4b Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Atg4b
autophagy related 4B, cysteine peptidase
MGI:1913865

28 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Atg4b^{Gt(A029E06)Wrst}/Atg4b^{Gt(A029E06)Wrst} involves: 129S2/SvPas * C57BL/6	abnormal lipid homeostasis	J:163712
	abnormal otolith morphology	J:163712
	abnormal utricle morphology	J:163712
	abnormal vestibular saccular macula morphology	J:163712
	absent otoliths	J:163712
	circling	J:163712
	enlarged otoliths	J:163712
	head tilt	J:163712
	impaired autophagy	J:163712
	impaired coordination	J:163712
	impaired swimming	J:163712
	normal nervous system phenotype	J:163712
Atg4b^{Gt(OST264114)Lex}/Atg4b^{Gt(OST264114)Lex} involves: 129S5/SvEvBrd * C57BL/6J	abnormal cerebellum deep nucleus morphology	J:186046
	abnormal motor learning	J:186046
	impaired coordination	J:186046
	normal nervous system phenotype	J:186046
	preweaning lethality, incomplete penetrance	J:186046
Atg4b^{tm1b(EUCOMM)Hmgu}/Atg4b^{tm1b(EUCOMM)Hmgu} C57BL/6N-Atg4b^{tm1b(EUCOMM)Hmgu}/H	abnormal retina morphology	J:211773
	abnormal tooth morphology	J:211773
	cataract	J:211773
	decreased circulating cholesterol level	J:211773
	decreased circulating HDL cholesterol level	J:211773
	decreased circulating serum albumin level	J:211773
	decreased circulating total protein level	J:211773
	decreased lean body mass	J:211773
	decreased prepulse inhibition	J:211773
	increased circulating alanine transaminase level	J:211773
	increased circulating alkaline phosphatase level	J:211773
	limb grasping	J:211773
	short tibia	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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