Tk2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tk2
thymidine kinase 2, mitochondrial
MGI:1913266

23 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tk2^tm1Anka/Tk2^tm1Anka involves: 129X1/SvJ * C57BL/6	abnormal adaptive thermogenesis	J:137664
	abnormal brown adipose tissue morphology	J:137664
	abnormal hepatocyte morphology	J:137664
	abnormal mitochondrial crista morphology	J:137664
	abnormal myocardial fiber morphology	J:137664
	absent subcutaneous adipose tissue	J:137664
	decreased body temperature	J:137664
	decreased mitochondrial DNA content	J:137664
	postnatal growth retardation	J:137664
	postnatal lethality, complete penetrance	J:137664
Tk2^tm1Mihi/Tk2^tm1Mihi involves: 129S6/SvEv * C57BL/6J	abnormal astrocyte morphology	J:139195
	abnormal brain morphology	J:166725
	abnormal gait	J:139195
	abnormal heart morphology	J:166725
	abnormal mitochondrial ATP synthesis coupled electron transport	J:139195
	abnormal nervous system morphology	J:139195
	abnormal spinal cord interneuron morphology	J:139195
	decreased locomotor activity	J:139195
	decreased mitochondrial DNA content	J:139195, J:166725
	decreased muscle fiber mitochondrial DNA content	J:166725
	decreased myocardial fiber mitochondrial DNA content	J:166725
	normal muscle phenotype	J:139195
	postnatal growth retardation	J:139195
	postnatal lethality, complete penetrance	J:139195
	tremors	J:139195
	weakness	J:139195

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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