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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Tk2
thymidine kinase 2, mitochondrial
MGI:1913266
21 phenotypes from 2 alleles in 2 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Tk2tm1Anka/Tk2tm1Anka
involves: 129X1/SvJ * C57BL/6
abnormal adaptive thermogenesis J:137664
abnormal brown adipose tissue morphology J:137664
abnormal hepatocyte morphology J:137664
abnormal mitochondrial crista morphology J:137664
abnormal myocardial fiber morphology J:137664
absent subcutaneous adipose tissue J:137664
decreased body temperature J:137664
decreased mitochondrial DNA content J:137664
postnatal growth retardation J:137664
postnatal lethality, complete penetrance J:137664
Tk2tm1Mihi/Tk2tm1Mihi
involves: 129S6/SvEv * C57BL/6J
abnormal astrocyte morphology J:139195
abnormal brain morphology J:166725
abnormal gait J:139195
abnormal heart morphology J:166725
abnormal mitochondrial ATP synthesis coupled electron transport J:139195
abnormal nervous system morphology J:139195
abnormal spinal cord interneuron morphology J:139195
decreased mitochondrial DNA content J:139195, J:166725
hypoactivity J:139195
normal muscle phenotype J:139195
postnatal growth retardation J:139195
postnatal lethality, complete penetrance J:139195
tremors J:139195
weakness J:139195

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory