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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Il21
interleukin 21
MGI:1890474
16 phenotypes from 3 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Il21tm1Lex/Il21tm1Lex
involves: 129S5/SvEvBrd * C57BL/6
abnormal CD4-positive, alpha beta T cell morphology J:137867
abnormal CD4-positive, alpha-beta T cell physiology J:137867
abnormal germinal center B cell physiology J:137867
abnormal spleen germinal center morphology J:137867
decreased germinal center B cell number J:137867
decreased IgG1 level J:137867
decreased spleen germinal center number J:137867
Il21tm1Lex/Il21tm1Lex
involves: 129S5/SvEvBrd * C57BL/6J
abnormal gamma-delta T cell morphology J:123351
abnormal interleukin level J:123351
abnormal T cell differentiation J:123351
decreased CD4-positive, alpha beta T cell number J:123351
decreased susceptibility to experimental autoimmune encephalomyelitis J:123351
increased susceptibility to experimental autoimmune encephalomyelitis J:137377
Il21tm1Llit/Il21tm1Llit
involves: 129 * C57BL/6J
abnormal class switch recombination J:114783
increased IgE level J:114783
Il21tm1Nutt/Il21+
involves: C57BL/6
no abnormal phenotype detected J:185372

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/28/2022
MGI 6.20
The Jackson Laboratory