Ap1s2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
MGI:1889383

23 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ap1s2^em1(IMPC)Mbp/Y C57BL/6N-Ap1s2^em1(IMPC)Mbp/MbpMmucd	impaired pupillary reflex	J:211773
Ap1s2^em1(IMPC)Mbp/Ap1s2^em1(IMPC)Mbp C57BL/6N-Ap1s2^em1(IMPC)Mbp/MbpMmucd	abnormal eye morphology	J:211773
	decreased fasting circulating glucose level	J:211773
	increased vertical activity	J:211773
	microphthalmia	J:211773
Ap1s2^tm1Pschu/Y involves: 129P2/OlaHsd * C57BL/6	abnormal adipose tissue development	J:216244
	abnormal fat cell differentiation	J:216244
	abnormal interscapular fat pad morphology	J:216244
	decreased body weight	J:216244
	decreased epididymal fat pad weight	J:216244
	decreased subcutaneous adipose tissue amount	J:216244
	decreased total body fat amount	J:216244
	normal homeostasis/metabolism phenotype	J:216244
	lipodystrophy	J:216244
Ap1s2^tm1Pschu/Ap1s2^tm1Pschu involves: 129P2/OlaHsd * C57BL/6	abnormal adipose tissue development	J:216244
	abnormal fat cell differentiation	J:216244
	abnormal interscapular fat pad morphology	J:216244
	abnormal response to novelty	J:218588
	abnormal synaptic vesicle clustering	J:218588
	abnormal synaptic vesicle morphology	J:218588
	abnormal synaptic vesicle number	J:218588
	abnormal synaptic vesicle recycling	J:218588
	decreased body weight	J:216244
	decreased locomotor activity	J:218588
	decreased subcutaneous adipose tissue amount	J:216244
	decreased total body fat amount	J:216244
	normal endocrine/exocrine gland phenotype	J:216244
	normal homeostasis/metabolism phenotype	J:216244
	impaired balance	J:218588
	impaired spatial learning	J:218588
	lipodystrophy	J:216244

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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