56 phenotypes from 5 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Sirt6tm1.1Cxd/Sirt6tm1.1Cxd Tg(Alb1-cre)1Dlr/0 involves: 129S6/SvEvTac * FVB/N	abnormal liver morphology	J:166368
	hepatic steatosis	J:166368
	increased circulating glucose level	J:166368
	increased liver weight	J:166368
Sirt6tm1a(EUCOMM)Wtsi/Sirt6+ C57BL/6N-Sirt6tm1a(EUCOMM)Wtsi/H	increased circulating cholesterol level	J:165965
	increased mean corpuscular hemoglobin concentration	J:165965
Sirt6tm1Fwa/Sirt6tm1Fwa involves: 129S6/SvEvTac * 129X1/SvJ	abnormal B cell differentiation	J:112817
	abnormal lymphopoiesis	J:112817
	colitis	J:112817
	decreased body length	J:229077
	decreased body size	J:112817
	decreased body weight	J:229077
	decreased bone marrow cell number	J:112817
	decreased bone mineral density	J:112817
	decreased cell proliferation	J:112817
	decreased circulating glucose level	J:112817
	decreased circulating insulin-like growth factor I level	J:112817
	decreased double-positive T cell number	J:112817
	decreased leukocyte cell number	J:112817
	decreased subcutaneous adipose tissue amount	J:112817
	increased cellular sensitivity to alkylating agents	J:112817
	increased cellular sensitivity to ionizing radiation	J:112817
	lethality at weaning, complete penetrance	J:112817
	lordokyphosis	J:112817
	postnatal growth retardation	J:112817
	spleen hypoplasia	J:112817
	spontaneous chromosome breakage	J:112817
Sirt6tm1Fwa/Sirt6tm1Fwa involves: 129S6/SvEvTac * BALB/cJ	abnormal cornea physiology	J:247143
	abnormal cornea stroma morphology	J:247143
	abnormal electroretinogram waveform feature	J:247143
	cornea scarring	J:247143
	cornea vascularization	J:247143
	decreased a-wave amplitude	J:247143
	decreased b-wave amplitude	J:247143
	decreased body weight	J:247143
	decreased circulating insulin level	J:247143
	decreased subcutaneous adipose tissue amount	J:247143
	normal homeostasis/metabolism phenotype	J:247143
	impaired glucose tolerance	J:247143
	increased cornea thickness	J:247143
	increased susceptibility to age-related retinal degeneration	J:247143
	premature death	J:247143
	prenatal lethality, incomplete penetrance	J:247143
	thin retina inner nuclear layer	J:247143
	thin retina outer nuclear layer	J:247143
Sirt6tm2.1Cxd/Sirt6tm2.1Cxd involves: 129S6/SvEvTac * NIH Black Swiss	abnormal eye morphology	J:167023
	abnormal glucose homeostasis	J:167023
	abnormal nursing	J:167023
	abnormal spleen physiology	J:167023
	decreased body size	J:167023
	decreased body weight	J:167023
	decreased bone mineral density	J:167023
	decreased circulating glucose level	J:167023
	decreased circulating insulin level	J:167023
	decreased subcutaneous adipose tissue amount	J:167023
	decreased total body fat amount	J:167023
	early cellular replicative senescence	J:167023
	hypoglycemia	J:167023
	increased insulin sensitivity	J:167023
	lordokyphosis	J:167023
	male infertility	J:167023
	malocclusion	J:167023
	narrow eye opening	J:167023
	premature aging	J:167023
	premature death	J:167023
	reduced female fertility	J:167023
Sirt6tm2.2Cxd/Sirt6tm2.2Cxd involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss	abnormal eye morphology	J:167023
	abnormal glucose homeostasis	J:167023
	abnormal nursing	J:167023
	abnormal spleen physiology	J:167023
	decreased body size	J:167023
	decreased body weight	J:167023
	decreased bone mineral density	J:167023
	decreased circulating glucose level	J:167023
	decreased circulating insulin level	J:167023
	decreased subcutaneous adipose tissue amount	J:167023
	decreased total body fat amount	J:167023
	early cellular replicative senescence	J:167023
	hypoglycemia	J:167023
	increased insulin sensitivity	J:167023
	lordokyphosis	J:167023
	male infertility	J:167023
	malocclusion	J:167023
	narrow eye opening	J:167023
	premature aging	J:167023
	premature death	J:167023
	reduced female fertility	J:167023