About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Epm2a
epilepsy, progressive myoclonic epilepsy, type 2 gene alpha
MGI:1341085
39 phenotypes from 2 alleles in 4 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Epm2aTg(TcraK,TcrbK)TG-BFlv/Epm2a+
involves: C57BL/6 * C57BL/10 * C57BR/cd * CBA/J
abnormal DNA methylation J:112696
increased T cell derived lymphoma incidence J:112696
premature death J:112696
Epm2aTg(TcraK,TcrbK)TG-BFlv/Epm2a+
involves: C57BL/6J * CBA/J
increased CD8-positive, alpha-beta T cell number J:107545
Epm2atm1Kzy/Epm2atm1Kzy
involves: 129P2/OlaHsd
Lafora bodies J:181559
Epm2atm1Kzy/Epm2atm1Kzy
involves: 129P2/OlaHsd * C57BL/6J
abnormal brain wave pattern J:76688
abnormal enzyme/coenzyme level J:173769
abnormal heart morphology J:173769
abnormal passive avoidance behavior J:76688
ataxia J:76688
axon degeneration J:76688
decreased grip strength J:76688
hepatic steatosis J:173769
hippocampal neuron degeneration J:76688
hypoglycemia J:173769
impaired balance J:76688
impaired coordination J:76688
improved glucose tolerance J:173769
increased body fat mass J:173769
increased body weight J:173769
increased cardiac cell glucose uptake J:173769
increased cardiac muscle glycogen level J:173769
increased circulating cholesterol level J:173769
increased circulating free fatty acid level J:173769
increased circulating ketone body level J:173769
increased circulating triglyceride level J:173769
increased energy expenditure J:173769
increased fluid intake J:173769
increased insulin sensitivity J:173769
increased liver cholesterol level J:173769
increased liver triglyceride level J:173769
increased neuron apoptosis J:76688
increased oxygen consumption J:173769
increased respiratory quotient J:173769
increased startle reflex J:76688
Lafora bodies J:76688, J:173769
muscle weakness J:76688
myoclonus J:76688
polyphagia J:173769
Purkinje cell degeneration J:76688

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/14/2019
MGI 6.14
The Jackson Laboratory