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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Smad6
SMAD family member 6
MGI:1336883
24 phenotypes from 2 alleles in 2 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Smad6b2b390Clo/Smad6b2b390Clo
C57BL/6J-Smad6b2b390Clo
d-loop transposition of the great arteries J:175213
double outlet right ventricle J:175213
muscular ventricular septal defect J:175213
overriding aortic valve J:175213
perimembraneous ventricular septal defect J:175213
tricuspid valve atresia J:175213
Smad6tm1Glvn/Smad6tm1Glvn
involves: 129S6/SvEvTac * BALB/cByJ
abnormal aorta morphology J:60214
abnormal blood vessel physiology J:60214
abnormal cardiac epithelial to mesenchymal transition J:60214
abnormal cardiovascular system physiology J:60214
abnormal coronary vessel morphology J:60214
abnormal endocardium morphology J:60214
abnormal heart morphology J:60214
abnormal heart valve morphology J:60214
abnormal thrombosis J:60214
abnormal truncus arteriosus septation J:60214
decreased vasodilation J:60214
enlarged mitral valve J:60214
enlarged pulmonary valve J:60214
heart valve hyperplasia J:60214
increased systemic arterial blood pressure J:60214
normal mortality/aging J:60214
poor circulation J:60214
preweaning lethality, incomplete penetrance J:60214

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/14/2019
MGI 6.14
The Jackson Laboratory