Vamp8 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Vamp8
vesicle-associated membrane protein 8
MGI:1336882

29 phenotypes from 3 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Vamp8^{Gt(OST20346)Lex}/Vamp8^{Gt(OST20346)Lex} involves: 129S5/SvEvBrd * C57BL/6	abnormal mast cell physiology	J:131926
Vamp8^tm1.1Hong/Vamp8^tm1.1Hong 129-Vamp8^tm1.1Hong	increased blood osmolality	J:156248
	increased circulating renin level	J:156248
	kidney atrophy	J:156248
Vamp8^tm1.1Hong/Vamp8^tm1.1Hong B6.129P2-Vamp8^tm1.1Hong	dilated kidney collecting duct	J:156248
	hydronephrosis	J:156248
	postnatal lethality, incomplete penetrance	J:156248
	premature death	J:156248
Vamp8^tm1.1Hong/Vamp8^tm1.1Hong involves: 129P2/OlaHsd * BALB/cJ * C57BL/6	colorless urine	J:156248
	decreased urine osmolality	J:156248
	hydronephrosis	J:156248
	increased fluid intake	J:156248
	kidney atrophy	J:156248
	kidney degeneration	J:156248
	kidney medulla atrophy	J:156248
Vamp8^tm1Hong/Vamp8^tm1Hong involves: 129P2/OlaHsd * C57BL/6	abnormal circulating amylase level	J:137704
	abnormal circulating lipase level	J:137704
	abnormal dendritic cell physiology	J:131528
	abnormal enzyme/coenzyme activity	J:137704
	abnormal pancreas secretion	J:137704
	abnormal pancreatic acinar cell morphology	J:93035
	abnormal pancreatic acinar cell zymogen granule morphology	J:137704
	abnormal type I hypersensitivity reaction	J:133439
	decreased mast cell degranulation	J:133439
	decreased susceptibility to induced pancreatitis	J:137704
	normal immune system phenotype	J:133439
	pancreatic acinar cell zymogen granule accumulation	J:93035
	postnatal growth retardation	J:93035
	postnatal lethality, incomplete penetrance	J:93035
Vamp8^tm1Hong/Vamp8^tm1Hong involves: 129P2/OlaHsd * C57BL/6J	abnormal platelet activation	J:121010
	abnormal platelet physiology	J:121010
	normal hematopoietic system phenotype	J:121010

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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