79 phenotypes from 6 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Bub1bGt(neo-btk)1Dai/Bub1b+ involves: 129S4/SvJae	abnormal mitotic spindle assembly checkpoint	J:88094
	increased colon adenoma incidence	J:88094
	increased intestinal adenocarcinoma incidence	J:88094
Bub1bGt(neo-btk)1Dai/Bub1b+ involves: 129S4/SvJae * C57BL/6	abnormal definitive hematopoiesis	J:88223
	abnormal megakaryocyte differentiation	J:88223
	absent common myeloid progenitor cells	J:88223
	decreased erythrocyte cell number	J:88223
	normal embryo phenotype	J:88223
	enlarged spleen	J:88223
Bub1bGt(neo-btk)1Dai/Bub1bGt(neo-btk)1Dai involves: 129S4/SvJae * C57BL/6	abnormal blastocyst morphology	J:88223
	embryonic lethality between implantation and placentation, complete penetrance	J:88223
	increased embryonic tissue cell apoptosis	J:88223
Bub1btm1.1Hsl/Bub1b+ involves: 129 * C57BL/6	enlarged spleen	J:201641
	increased adenocarcinoma incidence	J:201641
	increased B cell derived lymphoma incidence	J:201641
	increased B cell proliferation	J:201641
	increased fibrosarcoma incidence	J:201641
	increased hemangiosarcoma incidence	J:201641
	increased hepatocellular carcinoma incidence	J:201641
	increased incidence of induced tumors	J:201641
	increased leukemia incidence	J:201641
	increased lung adenocarcinoma incidence	J:201641
	increased lymphoma incidence	J:201641
	increased rectum adenocarcinoma incidence	J:201641
	increased sarcoma incidence	J:201641
	increased spleen white pulp amount	J:201641
	normal mortality/aging	J:201641
Bub1btm1.1Hsl/Bub1b+ Tg(HIST1H2BB/EGFP)1Pa/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal cell nucleus morphology	J:201641
	abnormal mitosis	J:201641
	abnormal mitotic spindle assembly checkpoint	J:201641
	aneuploidy	J:201641
Bub1btm1.1Hsl/Bub1btm1.1Hsl involves: 129 * C57BL/6	abnormal embryo development	J:201641
	embryonic growth retardation	J:201641
	embryonic lethality between implantation and somite formation, complete penetrance	J:201641
	increased apoptosis	J:201641
Bub1btm1.1Jvd/Bub1b+ involves: 129S6/SvEvTac	abnormal cell cycle checkpoint function	J:105717
	premature death	J:194926
Bub1btm1.1Jvd/Bub1b+ involves: 129S6/SvEvTac * C57BL/6	abnormal mitosis	J:293084
	abnormal mitotic spindle assembly checkpoint	J:293084
	aneuploidy	J:293084
	decreased tumor latency	J:293084
	increased tumor growth/size	J:293084
	normal neoplasm	J:293084
	premature death	J:293084
Bub1btm1.1Jvd/Bub1btm1.1Jvd involves: 129S6/SvEvTac	embryonic lethality, complete penetrance	J:91128
Bub1btm1Jvd/Bub1b+ involves: 129S6/SvEvTac	abnormal cell cycle checkpoint function	J:105717
Bub1btm1Jvd/Bub1btm1.1Jvd involves: 129S6/SvEvTac	neonatal lethality, complete penetrance	J:91128
Bub1btm1Jvd/Bub1btm1.1Jvd involves: 129S6/SvEvTac * C57BL/6	neonatal lethality, complete penetrance	J:293084
Bub1btm1Jvd/Bub1btm1Jvd involves: 129S6/SvEvTac	abnormal cell cycle checkpoint function	J:105717
	abnormal cell physiology	J:91128
	abnormal cellular replicative senescence	J:91128, J:105717
	abnormal mitosis	J:105717
	cachexia	J:91128
	cataract	J:91128
	chromosome breakage	J:91128
	decreased subcutaneous adipose tissue amount	J:91128
	decreased total body fat amount	J:91128
	female infertility	J:91128
	impaired wound healing	J:91128
	lordokyphosis	J:91128
	male infertility	J:91128
	muscular atrophy	J:91128
	oligozoospermia	J:91128
	postnatal growth retardation	J:91128
	premature death	J:91128
	thin dermal layer	J:91128
Bub1btm1Jvd/Bub1btm1Jvd involves: 129S6/SvEvTac * C57BL/6	abnormal mitosis	J:293084
	abnormal mitotic spindle assembly checkpoint	J:293084
	abnormal mitotic spindle morphology	J:293084
	aneuploidy	J:293084
	cataract	J:293084
	decreased fat cell size	J:293084
	decreased grip strength	J:293084
	early cellular replicative senescence	J:293084
	impaired exercise endurance	J:293084
	increased response of heart to induced stress	J:293084
	kyphosis	J:293084
	lipodystrophy	J:293084
	premature aging	J:293084
	premature death	J:293084
	skeletal muscle fiber atrophy	J:293084
Bub1btm1Jvd/Bub1btm1Jvd involves: 129S6/SvEvTac * C57BL/6 * FVB	abnormal hepatocyte physiology	J:234643
	aneuploidy	J:234643
	hypoglycemia	J:234643
	improved glucose tolerance	J:234643
	increased insulin sensitivity	J:234643
	postnatal growth retardation	J:234643
Bub1btm1Jvd/Bub1btm2.1Jvd involves: 129S6/SvEvTac * C57BL/6	abnormal mitosis	J:293084
	abnormal mitotic spindle assembly checkpoint	J:293084
	abnormal mitotic spindle morphology	J:293084
	aneuploidy	J:293084
	neonatal lethality, complete penetrance	J:293084
Bub1btm1Jvd/Bub1btm3.1Jvd involves: 129S6/SvEvTac * C57BL/6	abnormal mitosis	J:293084
	abnormal mitotic spindle assembly checkpoint	J:293084
	abnormal mitotic spindle morphology	J:293084
	aneuploidy	J:293084
	cataract	J:293084
	decreased fat cell size	J:293084
	decreased grip strength	J:293084
	early cellular replicative senescence	J:293084
	impaired exercise endurance	J:293084
	increased incidence of tumors by chemical induction	J:293084
	increased response of heart to induced stress	J:293084
	increased tumor growth/size	J:293084
	kyphosis	J:293084
	lipodystrophy	J:293084
	normal neoplasm	J:293084
	postnatal growth retardation	J:293084
	premature aging	J:293084
	premature death	J:293084
	skeletal muscle fiber atrophy	J:293084
Bub1btm2.1Jvd/Bub1b+ involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6	abnormal fat pad morphology	J:194926
	abnormal mitosis	J:194926
	aneuploidy	J:194926
	normal cardiovascular system phenotype	J:194926
	cataract	J:194926
	decreased body weight	J:194926
	decreased fat cell size	J:194926
	decreased inguinal fat pad weight	J:194926
	decreased mesenteric fat pad weight	J:194926
	decreased skeletal muscle fiber diameter	J:194926
	decreased subcutaneous adipose tissue amount	J:194926
	decreased total body fat amount	J:194926
	early cellular replicative senescence	J:194926
	impaired exercise endurance	J:194926
	increased tumor growth/size	J:194926
	lordokyphosis	J:194926
	muscular atrophy	J:194926
	normal neoplasm	J:194926
	premature aging	J:194926
	premature death	J:194926
	normal skeleton phenotype	J:194926
Bub1btm2.1Jvd/Bub1b+ involves: 129S6/SvEvTac * C57BL/6	abnormal chromosome number	J:293084
	abnormal mitosis	J:293084
	abnormal mitotic spindle assembly checkpoint	J:293084
	abnormal mitotic spindle morphology	J:293084
	aneuploidy	J:293084
Bub1btm2.1Jvd/Bub1btm3.1Jvd involves: 129S6/SvEvTac * C57BL/6	embryonic lethality prior to tooth bud stage	J:293084
Bub1btm3.1Jvd/Bub1b+ involves: 129S6/SvEvTac * C57BL/6	abnormal chromosome number	J:293084
	abnormal mitosis	J:293084
	abnormal mitotic spindle assembly checkpoint	J:293084
	abnormal mitotic spindle morphology	J:293084
	aneuploidy	J:293084
	decreased tumor latency	J:293084
	increased tumor growth/size	J:293084
	normal mortality/aging	J:293084
	normal neoplasm	J:293084