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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Xrcc4
X-ray repair complementing defective repair in Chinese hamster cells 4
MGI:1333799
11 phenotypes from 2 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Tg(Cr2-cre)3Cgn/?
Xrcc4tm1Fwa/Xrcc4tm2Fwa
involves: 129P2/OlaHsd * 129S6/SvEvTac
abnormal class switch recombination J:150339
spontaneous chromosome breakage J:150339
Xrcc4tm1Fwa/Xrcc4tm1Fwa
involves: 129P2/OlaHsd
abnormal cell physiology J:110848
abnormal DNA repair J:120145
increased cellular sensitivity to gamma-irradiation J:120145
increased neuron apoptosis J:110848
spontaneous chromosome breakage J:120145
thin cerebral cortex J:110848
Xrcc4tm1Fwa/Xrcc4tm1Fwa
involves: 129P2/OlaHsd * C57BL/6
abnormal cerebral cortex morphology J:65218
fetal growth retardation J:65218
lethality throughout fetal growth and development, complete penetrance J:65218
thymus hypoplasia J:65218

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory