Sphk1 Phenotype Annotations

About Help FAQ

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sphk1
sphingosine kinase 1
MGI:1316649

16 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Sphk1^em1(IMPC)Mbp/Sphk1^em1(IMPC)Mbp C57BL/6N-Sphk1^em1(IMPC)Mbp/MbpMmucd	abnormal heart morphology	J:211773
	abnormal kidney morphology	J:211773
	abnormal skin morphology	J:211773
	abnormal spleen morphology	J:211773
	abnormal vitreous body morphology	J:211773
	cataract	J:211773
	enlarged heart	J:211773
	enlarged spleen	J:211773
	small kidney	J:211773
Sphk1^tm1.1Cgh/Sphk1^tm1.1Cgh involves: 129S4/SvJae * C57BL/6	abnormal myocardial fiber physiology	J:119827
Sphk1^tm1Npa/Sphk1^tm1Npa BALB/c-Sphk1^tm1Npa	increased B cell number	J:129314
Sphk1^tm1Rlp/Sphk1^tm1Rlp involves: 129S6/SvEvTac	abnormal cytokine level	J:133917
	decreased susceptibility to endotoxin shock	J:133917
	decreased susceptibility to induced morbidity/mortality	J:133917
	enlarged mesenteric lymph nodes	J:133917
Sphk1^tm1Rlp/Sphk1^tm1Rlp involves: 129S6/SvEvTac * C57BL/6	no abnormal phenotype detected	J:95168

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23