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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Rasgrp1
RAS guanyl releasing protein 1
MGI:1314635
55 phenotypes from 10 alleles in 12 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Rasgrp1lag/Rasgrp1lag
involves: 129 * C57BL/6
abnormal lymph node morphology J:85189
abnormal positive T cell selection J:85189
abnormal renal glomerular capsule morphology J:85189
abnormal renal glomerulus morphology J:85189
abnormal T cell physiology J:85189
decreased T cell proliferation J:85189
enlarged liver J:85189
enlarged lymph nodes J:85189
enlarged spleen J:85189
glomerulonephritis J:85189
increased B cell number J:85189
increased IgG level J:85189
increased susceptibility to systemic lupus erythematosus J:85189
increased T cell number J:85189
Rasgrp1m1Anu/Rasgrp1+
involves: C57BL/6JSfdAnu * CBA/J
increased anti-nuclear antigen antibody level J:207898
Rasgrp1m1Anu/Rasgrp1m1Anu
C57BL/6JSfdAnu-Rasgrp1m1Anu
abnormal T cell differentiation J:104190
autoimmune response J:104190
Rasgrp1m1Anu/Rasgrp1m1Anu
involves: C57BL/6JSfdAnu * CBA/J
abnormal CD4-positive, alpha beta T cell morphology J:207898
normal immune system phenotype J:207898
increased anti-nuclear antigen antibody level J:207898
increased effector memory CD4-positive, alpha-beta T cell number J:207898
Rasgrp1m1Btlr/Rasgrp1m1Btlr
C57BL/6J-Rasgrp1m1Btlr
abnormal humoral immune response J:265163
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number J:265163
decreased CD8-positive, naive alpha-beta T cell number J:265163
decreased IgM level J:265163
increased CD8-positive, alpha-beta memory T cell number J:265163
increased effector memory CD4-positive, alpha-beta T cell number J:265163
increased IgA level J:265163
increased IgE level J:265163
increased IgM level J:265163
increased NK cell number J:265163
Rasgrp1m2Anu/Rasgrp1m2Anu
C57BL/6NCrlAnu-Rasgrp1m2Anu
normal immune system phenotype J:104190
Rasgrp1m2Btlr/Rasgrp1m2Btlr
C57BL/6J-Rasgrp1m2Btlr
decreased CD4-positive, alpha beta T cell number J:265163
decreased CD8-positive, alpha-beta T cell number J:265163
decreased CD8-positive, naive alpha-beta T cell number J:265163
decreased single-positive T cell number J:265163
decreased T cell number J:265163
increased central memory CD4-positive, alpha-beta T cell number J:265163
increased central memory CD8 positive, alpha-beta T cell number J:265163
increased effector memory CD4-positive, alpha-beta T cell number J:265163
increased effector memory CD8-positive, alpha-beta T cell number J:265163
increased NK cell number J:265163
Rasgrp1m3Btlr/Rasgrp1m3Btlr
C57BL/6J-Rasgrp1m3Btlr
decreased CD4-positive, alpha beta T cell number J:265255
decreased CD8-positive, alpha-beta T cell number J:265255
decreased CD8-positive, naive alpha-beta T cell number J:265255
decreased single-positive T cell number J:265255
decreased T cell number J:265255
increased B cell number J:265255
increased B-1b cell number J:265255
increased central memory CD8 positive, alpha-beta T cell number J:265255
increased effector memory CD4-positive, alpha-beta T cell number J:265255
increased effector memory CD8-positive, alpha-beta T cell number J:265255
increased IgM level J:265255
increased neutrophil cell number J:265255
increased NK cell number J:265255
Rasgrp1M4Btlr/Rasgrp1M4Btlr
C57BL/6J-Rasgrp1M4Btlr
abnormal T cell morphology J:267490
Rasgrp1m5Btlr/Rasgrp1m5Btlr
C57BL/6J-Rasgrp1m5Btlr
increased NK cell number J:272846
Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz
B6.Cg-Rasgrp1tm1.1Wz
abnormal CD4-positive T cell differentiation J:225109
abnormal CD8-positive, alpha-beta T cell differentiation J:225109
abnormal immune system cell morphology J:225109
abnormal immune system organ morphology J:225109
abnormal immune system physiology J:225109
abnormal immunoglobulin level J:225109
abnormal T cell differentiation J:225109
decreased single-positive T cell number J:225109
decreased T cell proliferation J:225109
enlarged spleen J:225109
normal immune system phenotype J:225109
increased autoantibody level J:225109
increased CD4-positive, alpha-beta memory T cell number J:225109
increased IgE level J:225109
increased IgG1 level J:225109
increased single-positive T cell number J:225109
increased spleen weight J:225109
Rasgrp1tm1Jstn/Rasgrp1tm1Jstn
involves: 129P3/J
abnormal CD4-positive, alpha beta T cell morphology J:207898
abnormal double-positive T cell morphology J:207898
decreased CD4-positive, alpha beta T cell number J:207898
decreased CD8-positive, alpha-beta T cell number J:207898
Rasgrp1tm1Jstn/Rasgrp1tm1Jstn
involves: 129P3/J * C57BL/6J
abnormal humoral immune response J:108677
decreased B cell number J:108677
decreased thymocyte number J:108677
enlarged spleen J:108677
increased immunoglobulin level J:108677
increased plasma cell number J:108677

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory