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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Hcn4
hyperpolarization-activated, cyclic nucleotide-gated K+ 4
MGI:1298209
15 phenotypes from 8 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Hcn4tm1(cre/ERT2)Anlu/Hcn4+
Not Specified 		normal cardiovascular system phenotype J:139266
no abnormal phenotype detected J:139266
Hcn4tm1.1Ggc/Hcn4tm1.1Ggc
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129S/SvEv * C57BL/6 * FVB/N 		abnormal impulse conducting system conduction J:168248
abnormal sinoatrial node conduction J:168248
atrioventricular block J:168248
decreased heart rate J:168248
premature death J:168248
prolonged PQ interval J:168248
Hcn4tm1.1Jsr/Hcn4tm1.1Jsr
involves: 129/Sv * C57BL/6 		abnormal heart rate J:86988
embryonic lethality during organogenesis, complete penetrance J:86988
Hcn4tm1Jsr/Hcn4tm1(cre/ERT2)Anlu
involves: 129S1/Sv * 129X1/SvJ 		abnormal impulse conducting system conduction J:139266
decreased heart rate J:139266
sinoatrial block J:139266
Hcn4tm1Jsr/Hcn4tm1Jsr
Myl2tm1(cre)Krc/Myl2+
involves: 129 		embryonic lethality during organogenesis, complete penetrance J:86988
Hcn4tm1Nnka/Hcn4+
involves: C57BL/6NCrlj * CBA/JNCrlj 		abnormal nervous system electrophysiology J:207953
abnormal olfactory bulb glomerular layer morphology J:207953
small olfactory bulb J:207953
Hcn4tm1Sev/?
Not Specified 		no abnormal phenotype detected J:156167
Hcn4tm2.1(cre/ERT2)Sev/Hcn4tm2.1(cre/ERT2)Sev
involves: Black Swiss * C57BL/6J 		embryonic lethality, complete penetrance J:101977
Hcn4tm3Sev/Hcn4tm3Sev
involves: Black Swiss * C57BL/6J 		embryonic lethality, complete penetrance J:101977
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory