Rif1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rif1
replication timing regulatory factor 1
MGI:1098622

23 phenotypes from 6 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Rif1^{Gt(A045A01)Wrst}/Rif1^{Gt(A045A01)Wrst} involves: 129S2/SvPas * C57BL/6J	abnormal mitosis	J:155449
	decreased cell proliferation	J:155449
	embryonic lethality during organogenesis, incomplete penetrance	J:155449
	postnatal growth retardation	J:155449
	postnatal lethality, incomplete penetrance	J:155449
	reduced fertility	J:155449
Rif1^{Gt(XT0278)Wtsi}/Rif1^{Gt(XT0278)Wtsi} involves: 129P2/OlaHsd * CD-1 * MF1	abnormal class switch recombination	J:195061
	abnormal DNA repair	J:195061
	abnormal double-strand DNA break repair	J:195061
	decreased IgA level	J:195061
	decreased IgG1 level	J:195061
	decreased IgG2b level	J:195061
	decreased IgG3 level	J:195061
	decreased IgG level	J:195061
	normal immune system phenotype	J:195061
	increased cellular sensitivity to ionizing radiation	J:195061
	increased susceptibility to bacterial infection	J:195061
	preweaning lethality, complete penetrance	J:195061
	preweaning lethality, incomplete penetrance	J:195061
Rif1^{Gt(XT0278)Wtsi}/Rif1^{Gt(XT0278)Wtsi} involves: 129P2/OlaHsd * MF1	embryonic growth retardation	J:195061
	preweaning lethality, complete penetrance	J:195061
Rif1^MommeD18/Rif1⁺ Tg(HBA1-GFP)1Ew/Tg(HBA1-GFP)1Ew involves: C57BL/6J * FVB/N	abnormal epigenetic regulation of gene expression	J:201508
Rif1^tm1.1Sbcb/Rif1^tm1.1Sbcb involves: C57BL/6 * C57BL/6J	decreased cell proliferation	J:155449
Rif1^tm2Sbcb/Rif1^tm2Sbcb involves: C57BL/6J	embryonic lethality, complete penetrance	J:155449
Rif1^tm3.1Sbcd/Rif1^tm3.1Sbcd involves: C57BL/6 * C57BL/6J	no abnormal phenotype detected	J:188030

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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