Psmb10 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Psmb10
proteasome (prosome, macropain) subunit, beta type 10
MGI:1096380

28 phenotypes from 2 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Psmb10^tm1Mgro/Psmb10^tm1Mgro involves: 129S2/SvPas * C57BL/6	abnormal CD8-positive, alpha-beta cytotoxic T cell morphology	J:125058
	abnormal cytotoxic T cell physiology	J:125058
	decreased CD8-positive, alpha-beta T cell number	J:125058
	decreased T cell proliferation	J:125058
Psmb10^tm1Mgro/Psmb10^Tub6 involves: 129S2/SvPas * C3HeB/FeJ	decreased NK cell number	J:261081
	decreased T cell number	J:261081
	increased granulocyte number	J:261081
	premature death	J:261081
Psmb10^Tub6/Psmb10⁺ C3HeB/FeJ-Psmb10^Tub6	abnormal T cell activation	J:261081
	decreased CD4-positive, alpha-beta T cell number	J:261081
	decreased CD8-positive, alpha-beta T cell number	J:261081
	decreased interferon-gamma secretion	J:261081
	decreased T cell number	J:261081
	increased susceptibility to bacterial infection induced morbidity/mortality	J:261081
Psmb10^Tub6/Psmb10^Tub6 B6.C3Fe-Psmb10^Tub6	increased granulocyte number	J:261081
Psmb10^Tub6/Psmb10^Tub6 C3HeB/FeJ-Psmb10^Tub6	absent lymph nodes	J:261081
	absent spleen white pulp	J:261081
	absent subcutaneous adipose tissue	J:261081
	alopecia	J:261081
	athymia	J:261081
	decreased B cell number	J:261081
	decreased body size	J:261081
	decreased immunoglobulin level	J:261081
	decreased leukocyte cell number	J:261081
	decreased NK cell number	J:261081
	decreased spleen red pulp amount	J:261081
	decreased T cell number	J:261081
	hyperkeratosis	J:261081
	increased circulating interleukin-1 level	J:261081
	increased circulating interleukin-6 level	J:261081
	increased circulating tumor necrosis factor level	J:261081
	increased granulocyte number	J:261081
	increased inflammatory response	J:261081
	premature death	J:261081
	skin inflammation	J:261081
Psmb10^Tub6/Psmb10^Tub6 C.C3Fe-Psmb10^Tub6	increased granulocyte number	J:261081

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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