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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Dnm2
dynamin 2
MGI:109547
71 phenotypes from 9 alleles in 11 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Dnm2b2b2159Clo/Dnm2b2b2159Clo
C57BL/6J-Dnm2b2b2159Clo
aorta hypoplasia J:175213
cleft palate J:175213
double outlet right ventricle J:175213
encephalomeningocele J:175213
hydrocephaly J:175213
hydronephrosis J:175213
microphthalmia J:175213
muscular ventricular septal defect J:175213
overriding aortic valve J:175213
perimembraneous ventricular septal defect J:175213
polycystic kidney J:175213
vascular ring J:175213
ventricular septal defect J:175213
Dnm2Rbc12/Dnm2+
involves: C57BL/6
abnormal bone marrow cell physiology J:330452
abnormal erythrocyte morphology J:330452
abnormal proerythroblast morphology J:330452
decreased hematocrit J:330452
decreased hemoglobin content J:330452
decreased mean corpuscular hemoglobin J:330452
normal homeostasis/metabolism phenotype J:330452
microcytic anemia J:330452
Dnm2Rbc12/Dnm2Rbc12
involves: C57BL/6
embryonic lethality prior to organogenesis J:330452
Dnm2tm1.1(KOMP)Vlcg/Dnm2+
C57BL/6N-Dnm2tm1.1(KOMP)Vlcg/Ucd
decreased mean corpuscular hemoglobin J:211773
enlarged uterus J:211773
hydrometra J:211773
increased circulating alkaline phosphatase level J:211773
small superior vagus ganglion J:211773
Dnm2tm1.1(KOMP)Vlcg/Dnm2tm1.1(KOMP)Vlcg
C57BL/6N-Dnm2tm1.1(KOMP)Vlcg/Ucd
embryonic lethality prior to organogenesis J:211773
embryonic lethality prior to tooth bud stage J:211773
preweaning lethality, incomplete penetrance J:211773
Dnm2tm1.1Ics/Dnm2+
involves: 129S2/SvPas
anemia J:330452
Dnm2tm1.1Ics/Dnm2+
involves: 129S2/SvPas * C57BL/6
abnormal calcium ion homeostasis J:237196
abnormal muscle contractility J:237196
abnormal skeletal muscle fiber morphology J:166364
decreased skeletal muscle fiber diameter J:166364
decreased skeletal muscle fiber size J:166364
decreased skeletal muscle mass J:166364
increased skeletal muscle fiber size J:166364
increased skeletal muscle mass J:166364
muscle weakness J:166364
muscular atrophy J:166364
Dnm2tm1.1Ics/Dnm2tm1.1Ics
involves: 129S2/SvPas * C57BL/6
abnormal cell physiology J:166364
abnormal skeletal muscle fiber morphology J:166364
centrally nucleated skeletal muscle fibers J:166364
decreased birth weight J:166364
decreased skeletal muscle fiber size J:166364
lethality at weaning, incomplete penetrance J:166364
neonatal lethality, incomplete penetrance J:166364
postnatal growth retardation J:166364
Dnm2tm1.1Pdc/Dnm2tm1.1Pdc
involves: 129S1/SvImJ * C57BL/6 * SJL
no abnormal phenotype detected J:161127
Dnm2tm1.2Pdc/Dnm2+
involves: 129S1/SvImJ * C57BL/6
normal hematopoietic system phenotype J:330452
Dnm2tm1.2Pdc/Dnm2tm1.2Pdc
involves: 129S1/SvImJ * C57BL/6 * FVB/N * SJL
embryonic lethality, complete penetrance J:161127
Dnm2tm1Ueli/Dnm2tm2.1Ics
Tg(Mpz-cre)26Mes/0
involves: C57BL/6J * C57BL/6N * FVB/NTac
abnormal action potential J:288372
decreased nerve conduction velocity J:288372
demyelination J:288372
Dnm2tm2.1Ics/Dnm2+
involves: C57BL/6J
abnormal action potential J:288372
abnormal gait J:288372
abnormal muscle electrophysiology J:288372
abnormal neuromuscular synapse morphology J:288372
abnormal skeletal muscle fiber morphology J:288372
abnormal skeletal muscle fiber type ratio J:288372
normal behavior/neurological phenotype J:288372
decreased locomotor activity J:288372
decreased skeletal muscle fiber diameter J:288372
decreased skeletal muscle weight J:288372
decreased total tissue mass J:288372
normal immune system phenotype J:288372
increased macrophage cell number J:288372
increased myelin sheath thickness J:288372
myopathy J:288372
short stride length J:288372
Dnm2tm4.1Ics/Dnm2+
involves: C57BL/6N
abnormal mitochondrial crista morphology J:329580
abnormal mitochondrial shape J:329580
abnormal skeletal muscle fiber morphology J:329580
decreased body weight J:329580
decreased food intake J:329580
decreased grip strength J:329580
decreased skeletal muscle fiber size J:329580
normal homeostasis/metabolism phenotype J:329580
increased mitochondrial size J:329580
preweaning lethality, incomplete penetrance J:329580
Dnm2tm4.1Ics/Dnm2tm4.1Ics
involves: C57BL/6N
abnormal skeletal muscle fiber morphology J:329580
perinatal lethality, complete penetrance J:329580

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory