Dab2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dab2
disabled 2, mitogen-responsive phosphoprotein
MGI:109175

25 phenotypes from 5 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Dab2^tm1.1Cpr/Dab2^tm1.1Cpr involves: 129S4/SvJaeSor * C57BL/6	abnormal embryonic epiblast morphology	J:75911
	abnormal extraembryonic tissue morphology	J:75911
	abnormal gastrulation	J:75911
	abnormal inner cell mass apoptosis	J:75911
	abnormal visceral endoderm morphology	J:75911
	abnormal visceral yolk sac cavity morphology	J:75911
	absent allantois	J:75911
	absent amnion	J:75911
	absent anterior visceral endoderm	J:75911
	absent chorion	J:75911
	decreased embryo size	J:75911
	embryonic lethality during organogenesis, complete penetrance	J:75911
	small proamniotic cavity	J:75911
Dab2^tm1Cpr/Dab2^tm1.1Cpr Meox2^tm1(cre)Sor/Meox2⁺ involves: 129S4/SvJaeSor * C57BL/6	abnormal proximal convoluted tubule morphology	J:75911
	increased urine protein level	J:75911
Dab2^tm1Xxx/Dab2^tm1Xxx involves: 129S6/SvEvTac * C57BL/6	abnormal egg cylinder morphology	J:79862
	abnormal gastrulation	J:79862
	absent inner cell mass proliferation	J:79862
	embryonic lethality, complete penetrance	J:79862
Dab2^tm2.1Xxx/Dab2^tm2.2Xxx Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA	normal embryo phenotype	J:205046
	increased circulating cholesterol level	J:205046
	increased circulating LDL cholesterol level	J:205046
	normal mortality/aging	J:205046
Dab2^tm2.1Xxx/Dab2^tm2.2Xxx Meox2^tm1(cre)Sor/Meox2⁺ involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J	normal mortality/aging	J:205046
Dab2^tm2.2Xxx/Dab2^tm2.2Xxx involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J	abnormal primitive endoderm morphology	J:205046
	disorganized extraembryonic tissue	J:205046
	embryonic lethality between implantation and placentation, complete penetrance	J:205046

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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