Ppp3ca Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
MGI:107164

25 phenotypes from 2 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ppp3ca^tm1Jse/Ppp3ca⁺ involves: 129S4/SvJae	abnormal urine osmolality	J:110350
Ppp3ca^tm1Jse/Ppp3ca^tm1Jse either: (involves: 129S4/SvJae * Black Swiss) or (involves: 129S4/SvJae * C57BL/6)	decreased interferon-gamma secretion	J:71750
	decreased interleukin-2 secretion	J:71750
	decreased interleukin-4 secretion	J:71750
	decreased T cell proliferation	J:71750
Ppp3ca^tm1Jse/Ppp3ca^tm1Jse involves: 129S4/SvJae	abnormal skeletal muscle fiber type ratio	J:110822
	decreased body weight	J:110350, J:110822
	decreased circulating calcium level	J:110350
	decreased circulating glucose level	J:110350
	decreased skeletal muscle fiber number	J:110822
	decreased urine creatinine level	J:110350
	decreased urine osmolality	J:110350
	increased blood urea nitrogen level	J:110350
	increased circulating creatinine level	J:110350
	increased skeletal muscle fiber diameter	J:110822
	premature death	J:110350
Ppp3ca^tm1Jse/Ppp3ca^tm1Jse involves: 129S4/SvJae * Black Swiss	abnormal hippocampal mossy fiber morphology	J:39103
Tg(Myh6-Ppp3ca)37Eno/0 involves: C57BL/6 * FVB	cardiac hypertrophy	J:227485
Tg(Myh6-Ppp3ca)37Eno/0 involves: C57BL/6 * FVB	premature death	J:227485
Tg(Myh6-Ppp3ca)37Eno/0 involves: FVB	cardiac hypertrophy	J:93176, J:94665, J:213308
	cardiac interstitial fibrosis	J:93176
	dilated heart left ventricle	J:93176
	dilated heart right ventricle	J:93176
	increased heart weight	J:109586, J:213308
	increased myocardial fiber size	J:94665
	myocardial fiber disarray	J:93176
	premature death	J:93176
	pulmonary edema	J:93176

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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