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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Scnn1b
sodium channel, nonvoltage-gated 1 beta
MGI:104696
33 phenotypes from 7 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Scnn1btm1.1Hum/Scnn1btm1.1Hum
involves: 129P2/OlaHsd
no abnormal phenotype detected J:144725
Scnn1btm1.1Ipt/Scnn1b+
involves: 129P2/OlaHsd * C57BL/6J * FVB/N
abnormal digestive system physiology J:59840
abnormal kidney morphology J:59840
decreased circulating aldosterone level J:59840
hypervolemia J:59840
hypokalemia J:59840
increased systemic arterial systolic blood pressure J:59840
Scnn1btm1.1Ipt/Scnn1btm1.1Ipt
involves: 129P2/OlaHsd * C57BL/6J * FVB/N
abnormal digestive system physiology J:59840
abnormal kidney morphology J:59840
alkalosis J:59840
cardiac hypertrophy J:59840
decreased circulating aldosterone level J:59840
hypervolemia J:59840
hypokalemia J:59840
salt-sensitive hypertension J:59840
Scnn1btm1.2Hum/Scnn1btm1.2Hum
involves: 129P2/OlaHsd * FVB/N
postnatal lethality, complete penetrance J:144725
Scnn1btm1b(EUCOMM)Hmgu/Scnn1b+
C57BL/6N-Scnn1btm1b(EUCOMM)Hmgu/Cnrm
abnormal pelvic girdle bone morphology J:211773
absent vibrissae J:211773
decreased rib number J:211773
Scnn1btm1b(EUCOMM)Hmgu/Scnn1btm1b(EUCOMM)Hmgu
C57BL/6N-Scnn1btm1b(EUCOMM)Hmgu/Cnrm
preweaning lethality, complete penetrance J:211773
Scnn1btm1Ipt/Scnn1btm1Ipt
involves: 129P2/OlaHsd * C57BL/6J
no abnormal phenotype detected J:53057
Scnn1btm1Wsh/Scnn1btm1Wsh
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
abnormal urine homeostasis J:53058
decreased body weight J:53058
decreased circulating sodium level J:53058
increased circulating aldosterone level J:53058
increased circulating chloride level J:53058
increased circulating potassium level J:53058
neonatal lethality, complete penetrance J:53058
normal respiratory system phenotype J:53058
Tg(Scgb1a1-Scnn1b)6608Bouc/0
B6.Cg-Tg(Scgb1a1-Scnn1b)6608Bouc
abnormal mucociliary clearance J:191673
abnormal respiratory mucosa goblet cell morphology J:191673
abnormal respiratory system physiology J:191673
emphysema J:191673
postnatal lethality, incomplete penetrance J:191673
pulmonary epithelial necrosis J:191673
respiratory system inflammation J:191673
Tg(Scgb1a1-Scnn1b)6608Bouc/0
C.Cg-Tg(Scgb1a1-Scnn1b)6608Bouc
abnormal mucociliary clearance J:191673
abnormal respiratory mucosa goblet cell morphology J:191673
abnormal respiratory system physiology J:191673
emphysema J:191673
postnatal lethality, incomplete penetrance J:191673
pulmonary epithelial necrosis J:191673
respiratory system inflammation J:191673
Tg(Scgb1a1-Scnn1b)6608Bouc/0
involves: C3H * C57BL/6
abnormal mucociliary clearance J:91139
abnormal respiratory mucosa goblet cell morphology J:91139
abnormal respiratory system physiology J:91139
lung inflammation J:91139
postnatal lethality J:91139
respiratory distress J:91139

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/07/2017
MGI 6.11
The Jackson Laboratory