Cacnb3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cacnb3
calcium channel, voltage-dependent, beta 3 subunit
MGI:103307

22 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cacnb3^tm1Acv/Cacnb3^tm1Acv involves: 129S1/Sv * 129X1/SvJ	abnormal calcium ion homeostasis	J:86381
	abnormal CD4-positive, alpha-beta T cell physiology	J:115345
	abnormal interleukin secretion	J:115345
	abnormal vascular smooth muscle morphology	J:86381
	abnormal vascular smooth muscle physiology	J:86381
	decreased interferon-gamma secretion	J:115345
	enlarged heart	J:86381
	increased heart weight	J:86381
	increased systemic arterial blood pressure	J:86381
	increased systemic arterial diastolic blood pressure	J:86381
	increased systemic arterial systolic blood pressure	J:86381
	vascular smooth muscle hypertrophy	J:86381
Cacnb3^tm1Hssh/Cacnb3^tm1Hssh involves: 129/Sv * 129S4/SvJae	abnormal channel response	J:50152
	normal nervous system phenotype	J:50152
	normal vision/eye phenotype	J:80080
Cacnb3^tm1Hssh/Cacnb3^tm1Hssh involves: 129S4/SvJae * C57BL/6J	abnormal discrimination learning	J:136837
	abnormal optic tract morphology	J:72711
	abnormal sensory neuron innervation pattern	J:72711
	enhanced contextual conditioning behavior	J:136837
	enhanced long-term object recognition memory	J:136837
	enhanced long-term potentiation	J:136837
	enhanced NMDA-mediated synaptic currents	J:136837
	normal nervous system phenotype	J:136837

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23