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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Stat4
signal transducer and activator of transcription 4
MGI:103062
23 phenotypes from 4 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Stat4em1(IMPC)Mbp/Stat4em1(IMPC)Mbp
C57BL/6N-Stat4em1(IMPC)Mbp/MbpMmucd 		abnormal kidney morphology J:211773
corneal opacity J:211773
small kidney J:211773
Stat4ity14/Stat4ity14
involves: 129S1/Sv * 129X1/SvJ 		decreased circulating interferon-gamma level J:207092
decreased interferon-gamma secretion J:207092
increased circulating interleukin-12 level J:207092
increased susceptibility to bacterial infection J:207092
increased susceptibility to bacterial infection induced morbidity/mortality J:207092
Stat4ity14/Stat4tm1Gru
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ 		increased susceptibility to bacterial infection induced morbidity/mortality J:207092
Stat4tm1Gru/Stat4+
NOD.129S2-Stat4tm1Gru 		abnormal circulating glucose level J:90600
Stat4tm1Gru/Stat4tm1Gru
C.129S2-Stat4tm1Gru 		abnormal CD4-positive T cell differentiation J:143729
abnormal kidney physiology J:84825
decreased circulating interferon-gamma level J:90600
decreased circulating interleukin-2 level J:90600
Stat4tm1Gru/Stat4tm1Gru
involves: 129S2/SvPas 		abnormal cytokine secretion J:112600
Stat4tm1Gru/Stat4tm1Gru
involves: 129S2/SvPas * BALB/c 		abnormal lymphocyte physiology J:34059
abnormal NK cell physiology J:34059
abnormal T cell proliferation J:34059
abnormal T-helper 1 physiology J:34059
abnormal T-helper 2 physiology J:34059
decreased circulating interferon-gamma level J:163843
decreased interferon-gamma secretion J:34059
increased susceptibility to bacterial infection J:163843
increased susceptibility to bacterial infection induced morbidity/mortality J:163843
Stat4tm1Gru/Stat4tm1Gru
NOD.129S2-Stat4tm1Gru 		abnormal inflammatory response J:90600
abnormal insulin secretion J:90600
abnormal pancreatic beta cell morphology J:90600
decreased circulating interferon-gamma level J:90600
decreased circulating interleukin-2 level J:90600
decreased susceptibility to autoimmune diabetes J:90600
Stat4tm1Jni/Stat4tm1Jni
involves: 129P2/OlaHsd * C57BL/6 		abnormal NK cell physiology J:79552
decreased circulating interferon-gamma level J:79552
decreased susceptibility to autoimmune diabetes J:96338
increased interleukin-4 secretion J:96338
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory