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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		E2f4
E2F transcription factor 4
MGI:103012
14 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
E2f4tm1Jrn/E2f4tm1Jrn
E2f5tm1Dli/E2f5tm1Dli
involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6 		abnormal cell cycle J:64757
lethality throughout fetal growth and development, complete penetrance J:64757
E2f4tm1Lees/E2f4+
Rb1tm1Tyj/Rb1+
involves: 129S2/SvPas * C57BL/6 		increased pituitary gland tumor incidence J:81082
increased thyroid tumor incidence J:81082
premature death J:81082
E2f4tm1Lees/E2f4+
E2f5tm1Dli/E2f5tm1Dli
involves: 129S1/Sv * 129S4/SvJae * C57BL/6 		dilated seminiferous tubule J:228346
E2f4tm1Lees/E2f4tm1Lees
Rb1tm1Tyj/Rb1+
involves: 129S2/SvPas * C57BL/6 		decreased tumor incidence J:81082
increased susceptibility to infection J:81082
premature death J:81082
E2f4tm2.1Lees/E2f4+
E2f5tm1Dli/E2f5tm1Dli
involves: 129S1/Sv * 129S4/SvJae * C57BL/6 		abnormal efferent ductules of testis morphology J:228346
dilated rete testis J:228346
E2f4tm2.1Lees/E2f4tm2.1Lees
E2f5tm1Dli/E2f5+
Tg(Vil1-cre)20Syr/0
involves: 129S1/Sv * 129S4/SvJae * C57BL/6 * DBA/2 		abnormal efferent ductules of testis morphology J:228346
abnormal epididymis morphology J:228346
abnormal seminiferous tubule epithelium morphology J:228346
dilated rete testis J:228346
dilated seminiferous tubule J:228346
male infertility J:228346
normal reproductive system phenotype J:228346
E2f4tm2.1Lees/E2f4tm2.1Lees
E2f5tm1Dli/E2f5tm1Dli
involves: 129S1/Sv * 129S4/SvJae * C57BL/6 		abnormal efferent ductules of testis morphology J:228346
dilated rete testis J:228346
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory