Guca1a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Guca1a
guanylate cyclase activator 1a (retina)
MGI:102770

13 phenotypes from 5 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Guca1a/Guca1b^tm1Jnc/Guca1a⁺ involves: 129S1/Sv * C57BL/6	abnormal eye electrophysiology	J:83914
Guca1a/Guca1b^tm1Jnc/Guca1a/Guca1b^tm1Jnc involves: 129S1/Sv * C57BL/6	abnormal rod electrophysiology	J:83914, J:166744
Guca1a^tm1.1Hunt/Guca1a⁺ involves: 129	abnormal cone electrophysiology	J:171667
	abnormal eye electrophysiology	J:171667
	abnormal rod electrophysiology	J:171667
	decreased retina cone cell number	J:171667
	decreased retina photoreceptor cell number	J:171667
	retina photoreceptor degeneration	J:171667
	short photoreceptor outer segment	J:171667
	thin retina outer nuclear layer	J:171667
Guca1a^tm1.1Hunt/Guca1a^tm1.1Hunt involves: 129	abnormal cone electrophysiology	J:171667
	abnormal eye electrophysiology	J:171667
	abnormal rod electrophysiology	J:171667
	decreased retina cone cell number	J:171667
	decreased retina photoreceptor cell number	J:171667
	retina photoreceptor degeneration	J:171667
	short photoreceptor outer segment	J:171667
	thin retina outer nuclear layer	J:171667
Guca1a^tm1Itl/Guca1a^tm1Itl involves: 129S6/SvEvTac * C57BL/6NTac	abnormal photoreceptor outer segment morphology	J:192199
	abnormal retina morphology	J:192199
	abnormal rod electrophysiology	J:192199
Tg(Guca1aL151F)#Wbae/0 involves: C57BL/6J FVB/N	decreased a-wave amplitude	J:199392
	decreased b-wave amplitude	J:199392
	decreased visual acuity	J:199392
	retina photoreceptor degeneration	J:199392
	thin retina outer nuclear layer	J:199392
Tg(Guca1aL151F/EGFP)#Wbae/0 involves: C57BL/6J FVB/N	decreased a-wave amplitude	J:199392
	decreased b-wave amplitude	J:199392
	decreased visual acuity	J:199392
	retina photoreceptor degeneration	J:199392
	thin retina outer nuclear layer	J:199392

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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