Six3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Six3
sine oculis-related homeobox 3
MGI:102764

23 phenotypes from 5 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Six3^tm1Gco/Six3^tm1Gco involves: 129S1/Sv	abnormal craniofacial morphology	J:81797
	abnormal cranium morphology	J:81797
	abnormal forebrain development	J:81797
	abnormal neural tube morphology	J:81797
	abnormal rostral-caudal axis patterning	J:81797
	absent embryonic telencephalon	J:81797
	absent nasal placodes	J:81797
	absent optic pit	J:81797
	absent optic vesicle	J:81797
	anophthalmia	J:81797
	decreased forebrain size	J:81797
	increased midbrain size	J:81797
	perinatal lethality, complete penetrance	J:81797
Six3^tm2.1Gco/Six3^tm2.1Gco involves: 129S1/Sv	abnormal forebrain development	J:116102
Six3^tm2.1Gco/Six3^tm2.1Gco involves: 129S1/Sv	decreased forebrain size	J:116102
Six3^tm2Gco/Six3^tm2.1Gco Tg(CAG-cre/Esr1)5Amc/0 involves: 129S1/Sv C57BL/6 * CBA	abnormal lens development	J:116102
	abnormal lens fiber morphology	J:116102
	abnormal lens induction	J:116102
	abnormal lens morphology	J:116102
	abnormal lens vesicle development	J:116102
	abnormal optic vesicle formation	J:116102
	aphakia	J:116102
	cataract	J:116102
	small lens	J:116102
Six3^tm2Gco/Six3^tm2.1Gco Tg(Pax6-cre,GFP)1Pgr/0 involves: 129S1/Sv * FVB/N	abnormal forebrain development	J:116102
	abnormal lens induction	J:116102
Six3^tm3Gco/Six3^tm3Gco Foxg1^tm1(cre)Skm/Foxg1⁺ involves: 129S1/Sv * C57BL/6	holoprosencephaly	J:140315
Six3^{tm4(cre/ERT2)Gco}/Six3⁺ involves: 129S1/Sv * C57BL/6	holoprosencephaly	J:140315

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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