GO Annotations Graph

• Symbol: Prkd1
• Name: protein kinase D1
• ID: MGI:99879

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0004698	calcium-dependent protein kinase C activity	IEA	J:72245
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:206919
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0004697	protein kinase C activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:244223
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:155856
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0000421	autophagosome membrane	ISO	J:164563
Cellular Component	GO:0005938	cell cortex	IDA	J:63657
Cellular Component	GO:0005911	cell-cell junction	IDA	J:63657
Cellular Component	GO:0005737	cytoplasm	IDA	J:63657
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IDA	J:180493
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005634	nucleus	IDA	J:63657
Cellular Component	GO:0005886	plasma membrane	IDA	J:180493
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:63657
Cellular Component	GO:0005802	trans-Golgi network	ISO	J:164563
Cellular Component	GO:0005802	trans-Golgi network	IDA	J:180493
Biological Process	GO:0001525	angiogenesis	IEA	J:60000
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0034198	cellular response to amino acid starvation	ISO	J:164563
Biological Process	GO:0071447	cellular response to hydroperoxide	ISO	J:164563
Biological Process	GO:0034599	cellular response to oxidative stress	ISO	J:164563
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	ISO	J:164563
Biological Process	GO:0050829	defense response to Gram-negative bacterium	IMP	J:233673
Biological Process	GO:0007030	Golgi organization	ISO	J:164563
Biological Process	GO:0048193	Golgi vesicle transport	IMP	J:180493
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:164563
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:155856
Biological Process	GO:0060548	negative regulation of cell death	ISO	J:164563
Biological Process	GO:0007399	nervous system development	IEA	J:60000
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	ISO	J:164563
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	IMP	J:278187
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0010508	positive regulation of autophagy	ISO	J:164563
Biological Process	GO:0043536	positive regulation of blood vessel endothelial cell migration	ISO	J:164563
Biological Process	GO:0032793	positive regulation of CREB transcription factor activity	ISO	J:164563
Biological Process	GO:2001028	positive regulation of endothelial cell chemotaxis	ISO	J:164563
Biological Process	GO:0038033	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0010595	positive regulation of endothelial cell migration	ISO	J:164563
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	ISO	J:164563
Biological Process	GO:1901727	positive regulation of histone deacetylase activity	ISO	J:164563
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0010976	positive regulation of neuron projection development	ISO	J:164563
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly	IDA	J:244223
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	IMP	J:180571
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0042307	positive regulation of protein import into nucleus	IMP	J:233673
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:164563
Biological Process	GO:0089700	protein kinase D signaling	ISO	J:164563
Biological Process	GO:0089700	protein kinase D signaling	IBA	J:265628
Biological Process	GO:0006468	protein phosphorylation	IEA	J:72247
Biological Process	GO:0010837	regulation of keratinocyte proliferation	IMP	J:165839
Biological Process	GO:0051279	regulation of release of sequestered calcium ion into cytosol	IDA	J:194901
Biological Process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	ISO	J:164563