About   Help   FAQ
GO Annotations Graph
Symbol
Name
ID
Ryr2
ryanodine receptor 2, cardiac
MGI:99685

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:0005262calcium channel activityIDAJ:48277
Molecular FunctionGO:0005509calcium ion bindingIEAJ:72247
Molecular FunctionGO:0048763calcium-induced calcium release activityISOJ:155856
Molecular FunctionGO:0048763calcium-induced calcium release activityISOJ:164563
Molecular FunctionGO:0015278calcium-release channel activityISOJ:164563
Molecular FunctionGO:0005516calmodulin bindingIDAJ:122033
Molecular FunctionGO:0005516calmodulin bindingISOJ:164563
Molecular FunctionGO:0019899enzyme bindingIPIJ:156537
Molecular FunctionGO:0019899enzyme bindingIPIJ:186219
Molecular FunctionGO:0019899enzyme bindingIPIJ:115187
Molecular FunctionGO:0019899enzyme bindingISOJ:164563
Molecular FunctionGO:0042802identical protein bindingISOJ:164563
Molecular FunctionGO:0042802identical protein bindingIPIJ:222155
Molecular FunctionGO:0042802identical protein bindingIPIJ:222148
Molecular FunctionGO:0005216ion channel activityIEAJ:72247
Molecular FunctionGO:0097159organic cyclic compound bindingIPIJ:122033
Molecular FunctionGO:0005515protein bindingIPIJ:187976
Molecular FunctionGO:0005515protein bindingIPIJ:197247
Molecular FunctionGO:0005515protein bindingIPIJ:176005
Molecular FunctionGO:0005515protein bindingIPIJ:219041
Molecular FunctionGO:0034236protein kinase A catalytic subunit bindingISOJ:164563
Molecular FunctionGO:0034237protein kinase A regulatory subunit bindingISOJ:164563
Molecular FunctionGO:0019901protein kinase bindingIPIJ:130644
Molecular FunctionGO:0043621protein self-associationIMPJ:57615
Molecular FunctionGO:0005219ryanodine-sensitive calcium-release channel activityISOJ:155856
Molecular FunctionGO:0005219ryanodine-sensitive calcium-release channel activityIDAJ:87557
Molecular FunctionGO:0005219ryanodine-sensitive calcium-release channel activityISOJ:164563
Molecular FunctionGO:0005219ryanodine-sensitive calcium-release channel activityIDAJ:122033
Molecular FunctionGO:0097110scaffold protein bindingISOJ:155856
Molecular FunctionGO:0043924suramin bindingISOJ:164563
Cellular ComponentGO:0031672A bandISOJ:155856
Cellular ComponentGO:0034704calcium channel complexIDAJ:115187
Cellular ComponentGO:0034704calcium channel complexISOJ:164563
Cellular ComponentGO:0005737cytoplasmISOJ:155856
Cellular ComponentGO:0005829cytosolISOJ:155856
Cellular ComponentGO:0005783endoplasmic reticulumISOJ:155856
Cellular ComponentGO:0070062extracellular exosomeISOJ:164563
Cellular ComponentGO:0031234extrinsic component of cytoplasmic side of plasma membraneISOJ:155856
Cellular ComponentGO:0016021integral component of membraneICJ:87557
Cellular ComponentGO:0016020membraneISOJ:164563
Cellular ComponentGO:0016020membraneIDAJ:122033
Cellular ComponentGO:0043005neuron projectionISOJ:155856
Cellular ComponentGO:0005635nuclear envelopeISOJ:155856
Cellular ComponentGO:0005886plasma membraneISOJ:155856
Cellular ComponentGO:0043234protein complexISOJ:138112
Cellular ComponentGO:0043234protein complexISOJ:155856
Cellular ComponentGO:0042383sarcolemmaISOJ:155856
Cellular ComponentGO:0030017sarcomereIDAJ:159237
Cellular ComponentGO:0016529sarcoplasmic reticulumIDAJ:186219
Cellular ComponentGO:0016529sarcoplasmic reticulumIDAJ:176005
Cellular ComponentGO:0016529sarcoplasmic reticulumISOJ:164563
Cellular ComponentGO:0016529sarcoplasmic reticulumISOJ:155856
Cellular ComponentGO:0016529sarcoplasmic reticulumIDAJ:196115
Cellular ComponentGO:0033017sarcoplasmic reticulum membraneIDAJ:107249
Cellular ComponentGO:0033017sarcoplasmic reticulum membraneIDAJ:87932
Cellular ComponentGO:0033017sarcoplasmic reticulum membraneISOJ:155856
Cellular ComponentGO:0005790smooth endoplasmic reticulumIDAJ:202429
Cellular ComponentGO:0030018Z discISOJ:155856
Cellular ComponentGO:0030018colocalizes_with
Z disc
ISOJ:155856
Cellular ComponentGO:0030018Z discIDAJ:104643
Cellular ComponentGO:0030018Z discIDAJ:149895
Biological ProcessGO:0030509BMP signaling pathwayIDAJ:120067
Biological ProcessGO:0070588calcium ion transmembrane transportISOJ:155856
Biological ProcessGO:0070588calcium ion transmembrane transportIMPJ:174958
Biological ProcessGO:0006816calcium ion transportIDAJ:57615
Biological ProcessGO:0006816calcium ion transportIDAJ:87557
Biological ProcessGO:0006816calcium ion transportIMPJ:48277
Biological ProcessGO:0006816calcium ion transportISOJ:164563
Biological ProcessGO:0006816calcium ion transportIPIJ:104643
Biological ProcessGO:0060402calcium ion transport into cytosolISOJ:164563
Biological ProcessGO:0019722calcium-mediated signalingIMPJ:48277
Biological ProcessGO:0035584calcium-mediated signaling using intracellular calcium sourceISOJ:164563
Biological ProcessGO:0060070canonical Wnt signaling pathwayIDAJ:120067
Biological ProcessGO:0060048cardiac muscle contractionISOJ:164563
Biological ProcessGO:0003300cardiac muscle hypertrophyIMPJ:122033
Biological ProcessGO:0006874cellular calcium ion homeostasisIMPJ:48277
Biological ProcessGO:0071313cellular response to caffeineIDAJ:186219
Biological ProcessGO:0071313cellular response to caffeineIDAJ:77723
Biological ProcessGO:0071313cellular response to caffeineIDAJ:48277
Biological ProcessGO:0071313cellular response to caffeineISOJ:164563
Biological ProcessGO:0071872cellular response to epinephrine stimulusIMPJ:142170
Biological ProcessGO:0060401cytosolic calcium ion transportIMPJ:122033
Biological ProcessGO:0005513detection of calcium ionISOJ:164563
Biological ProcessGO:0003143embryonic heart tube morphogenesisIMPJ:48277
Biological ProcessGO:0072599establishment of protein localization to endoplasmic reticulumISOJ:164563
Biological ProcessGO:0034220ion transmembrane transportISOJ:155856
Biological ProcessGO:0006811ion transportIEAJ:72247
Biological ProcessGO:0006811ion transportIEAJ:60000
Biological ProcessGO:0003220left ventricular cardiac muscle tissue morphogenesisIMPJ:122033
Biological ProcessGO:0071421manganese ion transmembrane transportISOJ:155856
Biological ProcessGO:0007275multicellular organism developmentIEAJ:60000
Biological ProcessGO:0051481negative regulation of cytosolic calcium ion concentrationISOJ:155856
Biological ProcessGO:1901896positive regulation of calcium-transporting ATPase activityISOJ:164563
Biological ProcessGO:0010460positive regulation of heart rateIMPJ:77723
Biological ProcessGO:0010460positive regulation of heart rateIMPJ:77723
Biological ProcessGO:0010460positive regulation of heart rateIMPJ:122033
Biological ProcessGO:0051284positive regulation of sequestering of calcium ionISOJ:164563
Biological ProcessGO:0098735positive regulation of the force of heart contractionISOJ:164563
Biological ProcessGO:0086029Purkinje myocyte to ventricular cardiac muscle cell signalingIMPJ:142170
Biological ProcessGO:0098910regulation of atrial cardiac muscle cell action potentialISOJ:164563
Biological ProcessGO:0098904regulation of AV node cell action potentialISOJ:164563
Biological ProcessGO:0055117regulation of cardiac muscle contractionISOJ:164563
Biological ProcessGO:0010882regulation of cardiac muscle contraction by calcium ion signalingISOJ:164563
Biological ProcessGO:0010881regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionIGIJ:107733
Biological ProcessGO:0051480regulation of cytosolic calcium ion concentrationISOJ:155856
Biological ProcessGO:0002027regulation of heart rateIMPJ:142170
Biological ProcessGO:0002027regulation of heart rateISOJ:164563
Biological ProcessGO:0098907regulation of SA node cell action potentialISOJ:164563
Biological ProcessGO:0098911regulation of ventricular cardiac muscle cell action potentialISOJ:164563
Biological ProcessGO:0051209release of sequestered calcium ion into cytosolISOJ:155856
Biological ProcessGO:0051209release of sequestered calcium ion into cytosolISOJ:164563
Biological ProcessGO:0014808release of sequestered calcium ion into cytosol by sarcoplasmic reticulumIMPJ:77723
Biological ProcessGO:0014808release of sequestered calcium ion into cytosol by sarcoplasmic reticulumISOJ:164563
Biological ProcessGO:0014808release of sequestered calcium ion into cytosol by sarcoplasmic reticulumIDAJ:159237
Biological ProcessGO:0031000response to caffeineIDAJ:87557
Biological ProcessGO:0031000response to caffeineIDAJ:57615
Biological ProcessGO:0031000response to caffeineISOJ:164563
Biological ProcessGO:0051592response to calcium ionISOJ:155856
Biological ProcessGO:0001666response to hypoxiaIDAJ:145985
Biological ProcessGO:0032026response to magnesium ionISOJ:155856
Biological ProcessGO:0014850response to muscle activityISOJ:164563
Biological ProcessGO:0035994response to muscle stretchISOJ:164563
Biological ProcessGO:0051775response to redox stateISOJ:164563
Biological ProcessGO:0070296sarcoplasmic reticulum calcium ion transportISOJ:155856
Biological ProcessGO:0055085transmembrane transportIEAJ:72247
Biological ProcessGO:0006810transportIEAJ:60000
Biological ProcessGO:0097050type B pancreatic cell apoptotic processISOJ:164563
Biological ProcessGO:0097050type B pancreatic cell apoptotic processIMPJ:123988
Biological ProcessGO:0086005ventricular cardiac muscle cell action potentialIMPJ:142170
GO:0005218IDAJ:57615


Gene Ontology Evidence Code Abbreviations:

Experimental:
EXP
Inferred from experiment
IDA
Inferred from direct assay
IEP
Inferred from expression pattern
IGI
Inferred from genetic interaction
IMP
Inferred from mutant phenotype
IPI
Inferred from physical interaction
Homology:
IAS
Inferred from ancestral sequence
IBA
Inferred from biological aspect of ancestor
IBD
Inferred from biological aspect of descendant
IKR
Inferred from key residues
IMR
Inferred from missing residues
IRD
Inferred from rapid divergence
ISA
Inferred from sequence alignment
ISM
Inferred from sequence model
ISO
Inferred from sequence orthology
ISS
Inferred from sequence or structural similarity
Automated:
IEA
Inferred from electronic annotation
RCA
Reviewed computational analysis
Other:
IC
Inferred by curator
NAS
Non-traceable author statement
ND
No biological data available
TAS
Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/14/2017
MGI 6.11
The Jackson Laboratory