GO Annotations Graph

• Symbol: Ryr2
• Name: ryanodine receptor 2, cardiac
• ID: MGI:99685

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005262	calcium channel activity	IDA	J:48277
Molecular Function	GO:0005509	calcium ion binding	IEA	J:72247
Molecular Function	GO:0048763	calcium-induced calcium release activity	ISO	J:164563
Molecular Function	GO:0048763	calcium-induced calcium release activity	ISO	J:155856
Molecular Function	GO:0048763	calcium-induced calcium release activity	IBA	J:265628
Molecular Function	GO:0015278	calcium-release channel activity	ISO	J:164563
Molecular Function	GO:0015278	calcium-release channel activity	IDA	J:57615
Molecular Function	GO:0005516	calmodulin binding	ISO	J:164563
Molecular Function	GO:0005516	calmodulin binding	IDA	J:122033
Molecular Function	GO:0019899	enzyme binding	IPI	J:156537
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	IPI	J:115187
Molecular Function	GO:0019899	enzyme binding	IPI	J:186219
Molecular Function	GO:0042802	identical protein binding	IPI	J:222155
Molecular Function	GO:0042802	identical protein binding	IPI	J:222148
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0005216	monoatomic ion channel activity	IEA	J:72247
Molecular Function	GO:0097159	organic cyclic compound binding	IPI	J:122033
Molecular Function	GO:0005515	protein binding	IPI	J:219041
Molecular Function	GO:0005515	protein binding	IPI	J:187976
Molecular Function	GO:0005515	protein binding	IPI	J:263461
Molecular Function	GO:0005515	protein binding	IPI	J:263460
Molecular Function	GO:0005515	protein binding	IPI	J:107249
Molecular Function	GO:0005515	protein binding	IPI	J:197247
Molecular Function	GO:0005515	protein binding	IPI	J:176005
Molecular Function	GO:0005515	protein binding	IPI	J:105342
Molecular Function	GO:0034236	protein kinase A catalytic subunit binding	ISO	J:164563
Molecular Function	GO:0034237	protein kinase A regulatory subunit binding	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	IPI	J:130644
Molecular Function	GO:0043621	protein self-association	IMP	J:57615
Molecular Function	GO:0005219	ryanodine-sensitive calcium-release channel activity	ISO	J:155856
Molecular Function	GO:0005219	ryanodine-sensitive calcium-release channel activity	ISO	J:164563
Molecular Function	GO:0005219	ryanodine-sensitive calcium-release channel activity	IBA	J:265628
Molecular Function	GO:0005219	ryanodine-sensitive calcium-release channel activity	IDA	J:122033
Molecular Function	GO:0005219	ryanodine-sensitive calcium-release channel activity	IDA	J:87557
Molecular Function	GO:0097110	scaffold protein binding	ISO	J:155856
Molecular Function	GO:0043924	suramin binding	ISO	J:164563
Cellular Component	GO:0031672	A band	ISO	J:155856
Cellular Component	GO:0034704	calcium channel complex	IDA	J:115187
Cellular Component	GO:0034704	calcium channel complex	ISO	J:164563
Cellular Component	GO:0034704	calcium channel complex	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	ISO	J:155856
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	IC	J:87557
Cellular Component	GO:0016020	membrane	IDA	J:122033
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0005635	nuclear envelope	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:138112
Cellular Component	GO:0042383	sarcolemma	ISO	J:155856
Cellular Component	GO:0042383	sarcolemma	IBA	J:265628
Cellular Component	GO:0030017	sarcomere	IDA	J:159237
Cellular Component	GO:0016529	sarcoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0016529	sarcoplasmic reticulum	IDA	J:186219
Cellular Component	GO:0016529	sarcoplasmic reticulum	IDA	J:196115
Cellular Component	GO:0016529	sarcoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0016529	sarcoplasmic reticulum	IDA	J:176005
Cellular Component	GO:0033017	sarcoplasmic reticulum membrane	ISO	J:155856
Cellular Component	GO:0033017	sarcoplasmic reticulum membrane	IBA	J:265628
Cellular Component	GO:0033017	sarcoplasmic reticulum membrane	IDA	J:107249
Cellular Component	GO:0033017	sarcoplasmic reticulum membrane	IDA	J:87932
Cellular Component	GO:0005790	smooth endoplasmic reticulum	IBA	J:265628
Cellular Component	GO:0005790	smooth endoplasmic reticulum	IDA	J:202429
Cellular Component	GO:0030018	Z disc	ISO	J:155856
Cellular Component	GO:0030018	Z disc	ISO	J:164563
Cellular Component	GO:0030018	Z disc	ISO	J:155856
Cellular Component	GO:0030018	Z disc	IBA	J:265628
Cellular Component	GO:0030018	Z disc	IDA	J:104643
Cellular Component	GO:0030018	Z disc	IDA	J:149895
Biological Process	GO:0097553	calcium ion transmembrane import into cytosol	IMP	J:122033
Biological Process	GO:0070588	calcium ion transmembrane transport	ISO	J:155856
Biological Process	GO:0070588	calcium ion transmembrane transport	IMP	J:174958
Biological Process	GO:0006816	calcium ion transport	IMP	J:48277
Biological Process	GO:0006816	calcium ion transport	ISO	J:164563
Biological Process	GO:0006816	calcium ion transport	IDA	J:57615
Biological Process	GO:0006816	calcium ion transport	IPI	J:104643
Biological Process	GO:0006816	calcium ion transport	IDA	J:87557
Biological Process	GO:0060402	calcium ion transport into cytosol	ISO	J:164563
Biological Process	GO:0019722	calcium-mediated signaling	IMP	J:48277
Biological Process	GO:0019722	calcium-mediated signaling	IDA	J:122033
Biological Process	GO:0035584	calcium-mediated signaling using intracellular calcium source	ISO	J:164563
Biological Process	GO:0060048	cardiac muscle contraction	ISO	J:164563
Biological Process	GO:0003300	cardiac muscle hypertrophy	IMP	J:122033
Biological Process	GO:0071313	cellular response to caffeine	IDA	J:186219
Biological Process	GO:0071313	cellular response to caffeine	IDA	J:48277
Biological Process	GO:0071313	cellular response to caffeine	ISO	J:164563
Biological Process	GO:0071313	cellular response to caffeine	IDA	J:77723
Biological Process	GO:0071872	cellular response to epinephrine stimulus	IMP	J:142170
Biological Process	GO:0005513	detection of calcium ion	ISO	J:164563
Biological Process	GO:0003143	embryonic heart tube morphogenesis	IMP	J:48277
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:77723
Biological Process	GO:0072599	establishment of protein localization to endoplasmic reticulum	ISO	J:164563
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IMP	J:48277
Biological Process	GO:0003220	left ventricular cardiac muscle tissue morphogenesis	IMP	J:122033
Biological Process	GO:0071421	manganese ion transmembrane transport	ISO	J:155856
Biological Process	GO:0034220	monoatomic ion transmembrane transport	ISO	J:155856
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:72247
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0051481	negative regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:1901896	positive regulation of ATPase-coupled calcium transmembrane transporter activity	ISO	J:164563
Biological Process	GO:0010460	positive regulation of heart rate	IMP	J:77723
Biological Process	GO:0010460	positive regulation of heart rate	IMP	J:77723
Biological Process	GO:0010460	positive regulation of heart rate	IMP	J:122033
Biological Process	GO:0051284	positive regulation of sequestering of calcium ion	ISO	J:164563
Biological Process	GO:0098735	positive regulation of the force of heart contraction	ISO	J:164563
Biological Process	GO:0086029	Purkinje myocyte to ventricular cardiac muscle cell signaling	IMP	J:142170
Biological Process	GO:0098910	regulation of atrial cardiac muscle cell action potential	ISO	J:164563
Biological Process	GO:0098904	regulation of AV node cell action potential	ISO	J:164563
Biological Process	GO:0055117	regulation of cardiac muscle contraction	ISO	J:164563
Biological Process	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling	ISO	J:164563
Biological Process	GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	IGI	J:107733
Biological Process	GO:0051480	regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:0002027	regulation of heart rate	ISO	J:164563
Biological Process	GO:0002027	regulation of heart rate	IMP	J:142170
Biological Process	GO:0098907	regulation of SA node cell action potential	ISO	J:164563
Biological Process	GO:0098911	regulation of ventricular cardiac muscle cell action potential	ISO	J:164563
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	IDA	J:122033
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	ISO	J:164563
Biological Process	GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IDA	J:159237
Biological Process	GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	ISO	J:164563
Biological Process	GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IBA	J:265628
Biological Process	GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IMP	J:77723
Biological Process	GO:0031000	response to caffeine	ISO	J:164563
Biological Process	GO:0031000	response to caffeine	IDA	J:57615
Biological Process	GO:0031000	response to caffeine	IDA	J:87557
Biological Process	GO:0051592	response to calcium ion	ISO	J:155856
Biological Process	GO:0001666	response to hypoxia	IDA	J:145985
Biological Process	GO:0032026	response to magnesium ion	ISO	J:155856
Biological Process	GO:0014850	response to muscle activity	ISO	J:164563
Biological Process	GO:0035994	response to muscle stretch	ISO	J:164563
Biological Process	GO:0051775	response to redox state	ISO	J:164563
Biological Process	GO:0070296	sarcoplasmic reticulum calcium ion transport	ISO	J:155856
Biological Process	GO:0006941	striated muscle contraction	IBA	J:265628
Biological Process	GO:0055085	transmembrane transport	IEA	J:72247
Biological Process	GO:0097050	type B pancreatic cell apoptotic process	ISO	J:164563
Biological Process	GO:0097050	type B pancreatic cell apoptotic process	IMP	J:123988
Biological Process	GO:0086005	ventricular cardiac muscle cell action potential	IMP	J:142170