GO Annotations Graph

• Symbol: Abca1
• Name: ATP-binding cassette, sub-family A member 1
• ID: MGI:99607

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0140359	ABC-type transporter activity	IEA	J:72247
Molecular Function	GO:0034186	apolipoprotein A-I binding	ISO	J:164563
Molecular Function	GO:0034188	apolipoprotein A-I receptor activity	ISO	J:164563
Molecular Function	GO:0034185	apolipoprotein binding	ISO	J:164563
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0051117	ATPase binding	ISO	J:164563
Molecular Function	GO:0140326	ATPase-coupled intramembrane lipid transporter activity	IEA	J:72245
Molecular Function	GO:0042626	ATPase-coupled transmembrane transporter activity	ISO	J:155856
Molecular Function	GO:0042626	ATPase-coupled transmembrane transporter activity	IBA	J:265628
Molecular Function	GO:0120020	cholesterol transfer activity	ISO	J:164563
Molecular Function	GO:0120020	cholesterol transfer activity	IDA	J:94706
Molecular Function	GO:0120020	cholesterol transfer activity	IMP	J:94706
Molecular Function	GO:0140328	floppase activity	ISO	J:164563
Molecular Function	GO:0008035	high-density lipoprotein particle binding	ISO	J:155856
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0031210	phosphatidylcholine binding	ISO	J:164563
Molecular Function	GO:0090554	phosphatidylcholine floppase activity	ISO	J:164563
Molecular Function	GO:0090554	phosphatidylcholine floppase activity	IBA	J:265628
Molecular Function	GO:0090556	phosphatidylserine floppase activity	ISO	J:164563
Molecular Function	GO:0090556	phosphatidylserine floppase activity	IBA	J:265628
Molecular Function	GO:0005548	phospholipid transporter activity	ISO	J:164563
Molecular Function	GO:0005548	phospholipid transporter activity	IDA	J:94706
Molecular Function	GO:0005548	phospholipid transporter activity	IMP	J:94706
Molecular Function	GO:0005515	protein binding	IPI	J:200990
Molecular Function	GO:0005515	protein binding	IPI	J:36952
Molecular Function	GO:0005515	protein binding	IPI	J:104106
Molecular Function	GO:0005515	protein binding	IPI	J:200990
Molecular Function	GO:0008320	protein transmembrane transporter activity	IMP	J:266038
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:0031267	small GTPase binding	ISO	J:164563
Molecular Function	GO:0046623	sphingolipid floppase activity	ISO	J:164563
Molecular Function	GO:0019905	syntaxin binding	ISO	J:164563
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0030139	endocytic vesicle	ISO	J:164563
Cellular Component	GO:0005768	endosome	ISO	J:164563
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:200990
Cellular Component	GO:0005794	Golgi apparatus	IDA	J:63265
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	IBA	J:265628
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	IDA	J:63265
Cellular Component	GO:0097708	intracellular vesicle	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0045121	membrane raft	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0045335	phagocytic vesicle	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:63265
Cellular Component	GO:0005886	plasma membrane	IDA	J:94706
Cellular Component	GO:0005886	plasma membrane	IDA	J:85674
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IDA	J:154929
Biological Process	GO:0071300	cellular response to retinoic acid	IDA	J:154929
Biological Process	GO:0033344	cholesterol efflux	IMP	J:185098
Biological Process	GO:0033344	cholesterol efflux	ISO	J:164563
Biological Process	GO:0033344	cholesterol efflux	IMP	J:93331
Biological Process	GO:0033344	cholesterol efflux	IDA	J:94706
Biological Process	GO:0033344	cholesterol efflux	IMP	J:94706
Biological Process	GO:0033344	cholesterol efflux	IDA	J:85674
Biological Process	GO:0033344	cholesterol efflux	IMP	J:120283
Biological Process	GO:0042632	cholesterol homeostasis	ISO	J:164563
Biological Process	GO:0008203	cholesterol metabolic process	ISO	J:164563
Biological Process	GO:0008203	cholesterol metabolic process	IDA	J:72766
Biological Process	GO:0030301	cholesterol transport	ISO	J:155856
Biological Process	GO:0016197	endosomal transport	ISO	J:164563
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:120283
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:94706
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:63265
Biological Process	GO:0140115	export across plasma membrane	IMP	J:266038
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0034380	high-density lipoprotein particle assembly	ISO	J:164563
Biological Process	GO:0032367	intracellular cholesterol transport	ISO	J:164563
Biological Process	GO:0042158	lipoprotein biosynthetic process	ISO	J:155856
Biological Process	GO:0042158	lipoprotein biosynthetic process	IMP	J:94964
Biological Process	GO:0042158	lipoprotein biosynthetic process	IMP	J:84572
Biological Process	GO:0042157	lipoprotein metabolic process	IMP	J:93331
Biological Process	GO:0007040	lysosome organization	ISO	J:164563
Biological Process	GO:0002790	peptide secretion	IMP	J:93331
Biological Process	GO:0006911	phagocytosis, engulfment	IMP	J:63265
Biological Process	GO:0033700	phospholipid efflux	ISO	J:164563
Biological Process	GO:0033700	phospholipid efflux	IBA	J:265628
Biological Process	GO:0033700	phospholipid efflux	IMP	J:94706
Biological Process	GO:0033700	phospholipid efflux	IDA	J:94706
Biological Process	GO:0055091	phospholipid homeostasis	ISO	J:164563
Biological Process	GO:0045332	phospholipid translocation	ISO	J:164563
Biological Process	GO:0045332	phospholipid translocation	IMP	J:63265
Biological Process	GO:0015914	phospholipid transport	ISO	J:155856
Biological Process	GO:0060155	platelet dense granule organization	ISO	J:164563
Biological Process	GO:0010875	positive regulation of cholesterol efflux	IMP	J:91401
Biological Process	GO:0090108	positive regulation of high-density lipoprotein particle assembly	IMP	J:185098
Biological Process	GO:0006497	protein lipidation	IMP	J:104106
Biological Process	GO:0009306	protein secretion	ISO	J:164563
Biological Process	GO:0009306	protein secretion	IMP	J:266038
Biological Process	GO:0071806	protein transmembrane transport	IMP	J:266038
Biological Process	GO:0032489	regulation of Cdc42 protein signal transduction	ISO	J:164563
Biological Process	GO:0034616	response to laminar fluid shear stress	ISO	J:164563
Biological Process	GO:0043691	reverse cholesterol transport	ISO	J:164563
Biological Process	GO:0043691	reverse cholesterol transport	IMP	J:123959
Biological Process	GO:0023061	signal release	IMP	J:266038
Biological Process	GO:0023061	signal release	ISO	J:164563
Biological Process	GO:0055085	transmembrane transport	IEA	J:72247