GO Annotations Graph

• Symbol: Mc1r
• Name: melanocortin 1 receptor
• ID: MGI:99456

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:60000
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:72247
Molecular Function	GO:0004977	melanocortin receptor activity	IDA	J:155191
Molecular Function	GO:0004980	melanocyte-stimulating hormone receptor activity	ISO	J:164563
Molecular Function	GO:0004980	melanocyte-stimulating hormone receptor activity	IBA	J:265628
Molecular Function	GO:0004980	melanocyte-stimulating hormone receptor activity	IDA	J:45497
Molecular Function	GO:0005515	protein binding	IPI	J:45497
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IEA	J:72247
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IEA	J:60000
Biological Process	GO:0035556	intracellular signal transduction	IDA	J:155191
Biological Process	GO:0042438	melanin biosynthetic process	IMP	J:28766
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	ISO	J:164563
Biological Process	GO:0043473	pigmentation	IMP	MGI:MGI:87265
Biological Process	GO:0010739	positive regulation of protein kinase A signaling	IDA	J:155191
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	IDA	J:155191
Biological Process	GO:0090037	positive regulation of protein kinase C signaling	IDA	J:155191
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:155191
Biological Process	GO:0019233	sensory perception of pain	IMP	J:83404
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:0070914	UV-damage excision repair	ISO	J:164563