GO Annotations Graph

• Symbol: Adora1
• Name: adenosine A1 receptor
• ID: MGI:99401

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0001609	G protein-coupled adenosine receptor activity	ISO	J:155856
Molecular Function	GO:0001609	G protein-coupled adenosine receptor activity	IBA	J:265628
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:60000
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:72247
Molecular Function	GO:0001664	G protein-coupled receptor binding	ISO	J:155856
Molecular Function	GO:0031683	G-protein beta/gamma-subunit complex binding	ISO	J:155856
Molecular Function	GO:0031072	heat shock protein binding	ISO	J:155856
Molecular Function	GO:0032795	heterotrimeric G-protein binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:204158
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:155856
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0001883	purine nucleoside binding	ISO	J:155856
Cellular Component	GO:0032279	asymmetric synapse	ISO	J:155856
Cellular Component	GO:0030673	axolemma	ISO	J:155856
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:155856
Cellular Component	GO:0044305	calyx of Held	ISO	J:155856
Cellular Component	GO:0044297	cell body	ISO	J:155856
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0030425	dendrite	IBA	J:265628
Cellular Component	GO:0043197	dendritic spine	IDA	J:204158
Cellular Component	GO:0012505	endomembrane system	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:250701
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0045211	postsynaptic membrane	ISO	J:155856
Cellular Component	GO:0045211	postsynaptic membrane	ISO	J:155856
Cellular Component	GO:0048786	presynaptic active zone	ISO	J:155856
Cellular Component	GO:0042734	presynaptic membrane	ISO	J:155856
Cellular Component	GO:0042734	presynaptic membrane	ISO	J:155856
Cellular Component	GO:0045202	synapse	IBA	J:265628
Cellular Component	GO:0045202	synapse	IDA	J:204158
Cellular Component	GO:0043195	terminal bouton	ISO	J:155856
Biological Process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0050890	cognition	ISO	J:155856
Biological Process	GO:0050965	detection of temperature stimulus involved in sensory perception of pain	ISO	J:155856
Biological Process	GO:0060079	excitatory postsynaptic potential	ISO	J:155856
Biological Process	GO:0060079	excitatory postsynaptic potential	IDA	J:120963
Biological Process	GO:0055089	fatty acid homeostasis	ISO	J:155856
Biological Process	GO:0001973	G protein-coupled adenosine receptor signaling pathway	IEA	J:72247
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IBA	J:265628
Biological Process	GO:0140928	inhibition of non-skeletal tissue mineralization	ISO	J:250701
Biological Process	GO:0140928	inhibition of non-skeletal tissue mineralization	ISO	J:250701
Biological Process	GO:0050900	leukocyte migration	IGI	J:95142
Biological Process	GO:0016042	lipid catabolic process	ISO	J:155856
Biological Process	GO:0060292	long-term synaptic depression	IMP	J:204158
Biological Process	GO:0060292	long-term synaptic depression	IGI	J:204158
Biological Process	GO:0070254	mucus secretion	IGI	J:95142
Biological Process	GO:0002674	negative regulation of acute inflammatory response	ISO	J:155856
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0045776	negative regulation of blood pressure	ISO	J:155856
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0042323	negative regulation of circadian sleep/wake cycle, non-REM sleep	ISO	J:155856
Biological Process	GO:0042321	negative regulation of circadian sleep/wake cycle, sleep	ISO	J:155856
Biological Process	GO:0014050	negative regulation of glutamate secretion	ISO	J:155856
Biological Process	GO:0045822	negative regulation of heart contraction	ISO	J:155856
Biological Process	GO:0046888	negative regulation of hormone secretion	ISO	J:155856
Biological Process	GO:0050728	negative regulation of inflammatory response	IGI	J:95142
Biological Process	GO:0002686	negative regulation of leukocyte migration	IGI	J:95142
Biological Process	GO:0050995	negative regulation of lipid catabolic process	ISO	J:155856
Biological Process	GO:1900453	negative regulation of long-term synaptic depression	IGI	J:204158
Biological Process	GO:1900453	negative regulation of long-term synaptic depression	IMP	J:204158
Biological Process	GO:1900272	negative regulation of long-term synaptic potentiation	ISO	J:155856
Biological Process	GO:0070256	negative regulation of mucus secretion	IGI	J:95142
Biological Process	GO:0032900	negative regulation of neurotrophin production	ISO	J:155856
Biological Process	GO:0035814	negative regulation of renal sodium excretion	ISO	J:155856
Biological Process	GO:0032229	negative regulation of synaptic transmission, GABAergic	ISO	J:155856
Biological Process	GO:0051967	negative regulation of synaptic transmission, glutamatergic	ISO	J:155856
Biological Process	GO:0003085	negative regulation of systemic arterial blood pressure	ISO	J:155856
Biological Process	GO:0045777	positive regulation of blood pressure	ISO	J:155856
Biological Process	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity	ISO	J:155856
Biological Process	GO:0050996	positive regulation of lipid catabolic process	ISO	J:155856
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:155856
Biological Process	GO:1901216	positive regulation of neuron death	ISO	J:155856
Biological Process	GO:0032244	positive regulation of nucleoside transport	ISO	J:155856
Biological Process	GO:0002793	positive regulation of peptide secretion	ISO	J:155856
Biological Process	GO:0043268	positive regulation of potassium ion transport	ISO	J:155856
Biological Process	GO:0035307	positive regulation of protein dephosphorylation	ISO	J:155856
Biological Process	GO:0003084	positive regulation of systemic arterial blood pressure	ISO	J:155856
Biological Process	GO:0006612	protein targeting to membrane	ISO	J:155856
Biological Process	GO:0086004	regulation of cardiac muscle cell contraction	ISO	J:155856
Biological Process	GO:0055117	regulation of cardiac muscle contraction	ISO	J:155856
Biological Process	GO:0003093	regulation of glomerular filtration	IMP	J:102066
Biological Process	GO:0099509	regulation of presynaptic cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:0002087	regulation of respiratory gaseous exchange by nervous system process	ISO	J:155856
Biological Process	GO:0051930	regulation of sensory perception of pain	IMP	J:149872
Biological Process	GO:0051930	regulation of sensory perception of pain	IMP	J:205640
Biological Process	GO:0060087	relaxation of vascular associated smooth muscle	ISO	J:155856
Biological Process	GO:0001666	response to hypoxia	ISO	J:155856
Biological Process	GO:0010035	response to inorganic substance	ISO	J:250701
Biological Process	GO:0010035	response to inorganic substance	IMP	J:250701
Biological Process	GO:0014074	response to purine-containing compound	ISO	J:250701
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:0001659	temperature homeostasis	ISO	J:155856
Biological Process	GO:0070328	triglyceride homeostasis	ISO	J:155856
Biological Process	GO:0042311	vasodilation	ISO	J:155856