GO Annotations Graph

• Symbol: Vcl
• Name: vinculin
• ID: MGI:98927

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	IEA	J:60000
Molecular Function	GO:0003779	actin binding	IEA	J:72247
Molecular Function	GO:0051015	actin filament binding	IEA	J:72247
Molecular Function	GO:0045294	alpha-catenin binding	ISO	J:164563
Molecular Function	GO:0045294	alpha-catenin binding	IBA	J:265628
Molecular Function	GO:0008013	beta-catenin binding	IBA	J:265628
Molecular Function	GO:0002162	dystroglycan binding	ISO	J:164563
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:200373
Molecular Function	GO:0005515	protein binding	IPI	J:116379
Molecular Function	GO:0005515	protein binding	IPI	J:212352
Molecular Function	GO:0005515	protein binding	IPI	J:200373
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0005515	protein binding	IPI	J:201288
Molecular Function	GO:0005515	protein binding	IPI	J:193640
Molecular Function	GO:0005515	protein binding	IPI	J:227201
Molecular Function	GO:0031267	small GTPase binding	ISO	J:155856
Molecular Function	GO:0005198	structural molecule activity	IEA	J:72247
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Cellular Component	GO:0015629	actin cytoskeleton	IDA	J:166692
Cellular Component	GO:0005884	actin filament	ISO	J:155856
Cellular Component	GO:0005912	adherens junction	ISO	J:164563
Cellular Component	GO:0005912	adherens junction	IBA	J:265628
Cellular Component	GO:0005912	adherens junction	IDA	J:78855
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0044291	cell-cell contact zone	ISO	J:164563
Cellular Component	GO:0044291	cell-cell contact zone	IBA	J:265628
Cellular Component	GO:0005911	cell-cell junction	ISO	J:164563
Cellular Component	GO:0005911	cell-cell junction	IDA	J:87902
Cellular Component	GO:0005911	cell-cell junction	IDA	J:191757
Cellular Component	GO:0043034	costamere	ISO	J:73065
Cellular Component	GO:0043034	costamere	IDA	J:91191
Cellular Component	GO:0005737	cytoplasm	IDA	J:213085
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005856	cytoskeleton	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005916	fascia adherens	IDA	J:112534
Cellular Component	GO:0005916	fascia adherens	IDA	J:73178
Cellular Component	GO:0005925	focal adhesion	IDA	J:213085
Cellular Component	GO:0005925	focal adhesion	ISO	J:164563
Cellular Component	GO:0005925	focal adhesion	ISO	J:155856
Cellular Component	GO:0005925	focal adhesion	IDA	J:114718
Cellular Component	GO:0005925	focal adhesion	IBA	J:265628
Cellular Component	GO:0005925	focal adhesion	IDA	J:227201
Cellular Component	GO:0005925	focal adhesion	IDA	J:217307
Cellular Component	GO:0005925	focal adhesion	ISO	J:254431
Cellular Component	GO:0014704	intercalated disc	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0045121	membrane raft	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IDA	J:112534
Cellular Component	GO:0002102	podosome	IDA	J:129034
Cellular Component	GO:0061826	podosome ring	IDA	J:246351
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0042383	sarcolemma	IDA	J:243471
Cellular Component	GO:0042383	sarcolemma	ISO	J:155856
Cellular Component	GO:0001725	stress fiber	ISO	J:155856
Cellular Component	GO:0030018	Z disc	ISO	J:155856
Biological Process	GO:0034333	adherens junction assembly	ISO	J:164563
Biological Process	GO:0043297	apical junction assembly	ISO	J:164563
Biological Process	GO:0048675	axon extension	IGI	J:209602
Biological Process	GO:0048675	axon extension	IGI	J:209602
Biological Process	GO:0007155	cell adhesion	IBA	J:265628
Biological Process	GO:0007155	cell adhesion	IDA	J:80756
Biological Process	GO:0090136	epithelial cell-cell adhesion	ISO	J:164563
Biological Process	GO:0030032	lamellipodium assembly	IDA	J:80756
Biological Process	GO:0002009	morphogenesis of an epithelium	ISO	J:164563
Biological Process	GO:0034394	protein localization to cell surface	ISO	J:164563
Biological Process	GO:0030334	regulation of cell migration	IDA	J:80756
Biological Process	GO:1903140	regulation of establishment of endothelial barrier	ISO	J:164563
Biological Process	GO:0051893	regulation of focal adhesion assembly	ISO	J:164563
Biological Process	GO:1904702	regulation of protein localization to adherens junction	ISO	J:164563