GO Annotations Graph

• Symbol: Trf
• Name: transferrin
• ID: MGI:98821

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008199	ferric iron binding	ISO	J:155856
Molecular Function	GO:0008198	ferrous iron binding	ISO	J:164563
Molecular Function	GO:0034986	iron chaperone activity	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:193640
Molecular Function	GO:1990459	transferrin receptor binding	ISO	J:164563
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:164563
Cellular Component	GO:0045178	basal part of cell	ISO	J:164563
Cellular Component	GO:0009925	basal plasma membrane	ISO	J:164563
Cellular Component	GO:0005604	basement membrane	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0051286	cell tip	ISO	J:155856
Cellular Component	GO:0005905	clathrin-coated pit	ISO	J:164563
Cellular Component	GO:0005905	clathrin-coated pit	IDA	J:164083
Cellular Component	GO:0031410	cytoplasmic vesicle	ISO	J:164563
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0097433	dense body	ISO	J:170947
Cellular Component	GO:0005769	early endosome	ISO	J:164563
Cellular Component	GO:0005769	early endosome	IBA	J:265628
Cellular Component	GO:0005769	early endosome	IDA	J:198162
Cellular Component	GO:0005769	early endosome	IDA	J:201826
Cellular Component	GO:0030139	endocytic vesicle	ISO	J:92184
Cellular Component	GO:0030139	endocytic vesicle	IDA	J:80735
Cellular Component	GO:0030139	endocytic vesicle	ISO	J:94651
Cellular Component	GO:0005768	endosome	IDA	J:135168
Cellular Component	GO:0005768	endosome	IDA	J:198162
Cellular Component	GO:0005768	endosome	IDA	J:93351
Cellular Component	GO:0005768	endosome	IDA	J:193911
Cellular Component	GO:0005768	endosome	IDA	J:103440
Cellular Component	GO:0005576	extracellular region	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:1990712	HFE-transferrin receptor complex	ISO	J:164563
Cellular Component	GO:0005770	late endosome	ISO	J:164563
Cellular Component	GO:0016020	membrane	IMP	J:156519
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0055037	recycling endosome	ISO	J:164563
Cellular Component	GO:0055037	recycling endosome	IBA	J:265628
Cellular Component	GO:0055037	recycling endosome	IDA	J:115416
Cellular Component	GO:0055037	recycling endosome	IDA	J:142909
Cellular Component	GO:0031982	vesicle	ISO	J:164563
Cellular Component	GO:0030120	vesicle coat	ISO	J:189648
Biological Process	GO:0007015	actin filament organization	IDA	J:146763
Biological Process	GO:0019731	antibacterial humoral response	IBA	J:265628
Biological Process	GO:0071281	cellular response to iron ion	ISO	J:164563
Biological Process	GO:0070371	ERK1 and ERK2 cascade	IDA	J:146763
Biological Process	GO:0006879	intracellular iron ion homeostasis	ISO	J:164563
Biological Process	GO:0006826	iron ion transport	ISO	J:155856
Biological Process	GO:0006826	iron ion transport	IBA	J:265628
Biological Process	GO:0006826	iron ion transport	IMP	J:82711
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0030316	osteoclast differentiation	IDA	J:146763
Biological Process	GO:0045780	positive regulation of bone resorption	IDA	J:146763
Biological Process	GO:2000147	positive regulation of cell motility	IDA	J:146763
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:146763
Biological Process	GO:0031643	positive regulation of myelination	ISO	J:155856
Biological Process	GO:0070447	positive regulation of oligodendrocyte progenitor proliferation	ISO	J:155856
Biological Process	GO:0042327	positive regulation of phosphorylation	IDA	J:146763
Biological Process	GO:0048260	positive regulation of receptor-mediated endocytosis	ISO	J:164563
Biological Process	GO:0034756	regulation of iron ion transport	ISO	J:164563
Biological Process	GO:0009617	response to bacterium	IEP	J:190322
Biological Process	GO:0060395	SMAD protein signal transduction	IDA	J:45399