GO Annotations Graph

• Symbol: Th
• Name: tyrosine hydroxylase
• ID: MGI:98735

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016597	amino acid binding	ISO	J:155856
Molecular Function	GO:0035240	dopamine binding	ISO	J:155856
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0008199	ferric iron binding	ISO	J:155856
Molecular Function	GO:0008198	ferrous iron binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0005506	iron ion binding	IEA	J:72247
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0004497	monooxygenase activity	ISO	J:155856
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen	IEA	J:72247
Molecular Function	GO:0019825	oxygen binding	ISO	J:155856
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:155856
Molecular Function	GO:0036094	small molecule binding	ISO	J:155856
Molecular Function	GO:0034617	tetrahydrobiopterin binding	ISO	J:155856
Molecular Function	GO:0004511	tyrosine 3-monooxygenase activity	ISO	J:164563
Molecular Function	GO:0004511	tyrosine 3-monooxygenase activity	ISO	J:155856
Molecular Function	GO:0004511	tyrosine 3-monooxygenase activity	IBA	J:265628
Molecular Function	GO:0004511	tyrosine 3-monooxygenase activity	TAS	J:30273
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0030424	axon	IBA	J:265628
Cellular Component	GO:0030424	axon	IDA	J:125222
Cellular Component	GO:0030424	axon	IDA	J:98330
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:60151
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane	ISO	J:164563
Cellular Component	GO:0031410	cytoplasmic vesicle	ISO	J:164563
Cellular Component	GO:0030659	cytoplasmic vesicle membrane	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0033162	melanosome membrane	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0043005	neuron projection	ISO	J:164563
Cellular Component	GO:0043005	neuron projection	IDA	J:101575
Cellular Component	GO:0043005	neuron projection	IDA	J:101575
Cellular Component	GO:0043005	neuron projection	IDA	J:201110
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:96716
Cellular Component	GO:0043204	perikaryon	ISO	J:155856
Cellular Component	GO:0043204	perikaryon	IBA	J:265628
Cellular Component	GO:0043204	perikaryon	IDA	J:55767
Cellular Component	GO:0048471	perinuclear region of cytoplasm	IDA	J:279052
Cellular Component	GO:0005790	smooth endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0045202	synapse	IEA	J:60000
Cellular Component	GO:0008021	synaptic vesicle	ISO	J:155856
Cellular Component	GO:0043195	terminal bouton	ISO	J:155856
Biological Process	GO:0015842	aminergic neurotransmitter loading into synaptic vesicle	ISO	J:155856
Biological Process	GO:0009887	animal organ morphogenesis	IMP	J:24347
Biological Process	GO:0009072	aromatic amino acid metabolic process	IEA	J:72247
Biological Process	GO:0042423	catecholamine biosynthetic process	ISO	J:155856
Biological Process	GO:0042416	dopamine biosynthetic process	ISO	J:164563
Biological Process	GO:0006585	dopamine biosynthetic process from tyrosine	ISO	J:155856
Biological Process	GO:0006585	dopamine biosynthetic process from tyrosine	IBA	J:265628
Biological Process	GO:0006585	dopamine biosynthetic process from tyrosine	IMP	J:24347
Biological Process	GO:0006585	dopamine biosynthetic process from tyrosine	IMP	J:30273
Biological Process	GO:0006585	dopamine biosynthetic process from tyrosine	TAS	J:54692
Biological Process	GO:0006585	dopamine biosynthetic process from tyrosine	IDA	J:79010
Biological Process	GO:0042755	eating behavior	IGI	J:61883
Biological Process	GO:0042755	eating behavior	IMP	J:70162
Biological Process	GO:0042755	eating behavior	IGI	J:81841
Biological Process	GO:0042755	eating behavior	IMP	J:92829
Biological Process	GO:0048596	embryonic camera-type eye morphogenesis	IMP	J:105984
Biological Process	GO:0042418	epinephrine biosynthetic process	ISO	J:164563
Biological Process	GO:0042462	eye photoreceptor cell development	IMP	J:105984
Biological Process	GO:0007507	heart development	ISO	J:155856
Biological Process	GO:0007507	heart development	IBA	J:265628
Biological Process	GO:0007507	heart development	IMP	J:54692
Biological Process	GO:0007507	heart development	IMP	J:24347
Biological Process	GO:1990384	hyaloid vascular plexus regression	IMP	J:279052
Biological Process	GO:0007612	learning	IMP	J:87763
Biological Process	GO:0007626	locomotory behavior	IMP	J:70162
Biological Process	GO:0007626	locomotory behavior	IMP	J:87763
Biological Process	GO:0007626	locomotory behavior	IGI	J:81841
Biological Process	GO:0007617	mating behavior	IMP	J:51133
Biological Process	GO:0007613	memory	IMP	J:87763
Biological Process	GO:0042136	neurotransmitter biosynthetic process	IEA	J:60000
Biological Process	GO:0042421	norepinephrine biosynthetic process	ISO	J:164563
Biological Process	GO:0008016	regulation of heart contraction	IMP	J:30273
Biological Process	GO:0008016	regulation of heart contraction	IMP	J:24347
Biological Process	GO:0045471	response to ethanol	ISO	J:164563
Biological Process	GO:0045471	response to ethanol	IBA	J:265628
Biological Process	GO:0001666	response to hypoxia	ISO	J:164563
Biological Process	GO:0001666	response to hypoxia	ISO	J:155856
Biological Process	GO:0001666	response to hypoxia	IBA	J:265628
Biological Process	GO:0001963	synaptic transmission, dopaminergic	IMP	J:82388
Biological Process	GO:0001963	synaptic transmission, dopaminergic	IMP	J:92402
Biological Process	GO:0007601	visual perception	IMP	J:105984