GO Annotations Graph

• Symbol: Cripto
• Name: cripto, EGF-CFC family member
• ID: MGI:98658

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0015026	coreceptor activity	IDA	J:190004
Molecular Function	GO:0008083	growth factor activity	ISO	J:164563
Molecular Function	GO:0008083	growth factor activity	ISO	J:18846
Molecular Function	GO:0038100	nodal binding	IPI	J:183227
Molecular Function	GO:0005515	protein binding	IPI	J:245350
Molecular Function	GO:0005515	protein binding	IPI	J:130239
Molecular Function	GO:0005515	protein binding	IPI	J:104371
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	IBA	J:265628
Molecular Function	GO:0070698	type I activin receptor binding	IPI	J:183227
Molecular Function	GO:0070698	type I activin receptor binding	IPI	J:190004
Molecular Function	GO:0017147	Wnt-protein binding	IPI	J:157442
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009986	cell surface	IBA	J:265628
Cellular Component	GO:0009986	cell surface	IDA	J:130239
Cellular Component	GO:0005737	cytoplasm	IDA	J:27180
Cellular Component	GO:0005737	cytoplasm	IDA	J:137356
Cellular Component	GO:0005576	extracellular region	IDA	J:183227
Cellular Component	GO:0005576	extracellular region	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IDA	J:60356
Cellular Component	GO:0005794	Golgi apparatus	IDA	J:27180
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0045121	membrane raft	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:27180
Cellular Component	GO:0048471	perinuclear region of cytoplasm	IDA	J:27180
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-1181357
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-1225898
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-NUL-1181349
Cellular Component	GO:0005886	plasma membrane	IDA	J:60356
Cellular Component	GO:0005886	plasma membrane	TAS	J:76538
Biological Process	GO:0048856	anatomical structure development	IBA	J:265628
Biological Process	GO:0009948	anterior/posterior axis specification	IGI	J:132584
Biological Process	GO:0008595	anterior/posterior axis specification, embryo	IMP	J:50343
Biological Process	GO:0055007	cardiac muscle cell differentiation	IMP	J:51595
Biological Process	GO:0030154	cell differentiation	TAS	J:74309
Biological Process	GO:0048144	fibroblast proliferation	IMP	J:51595
Biological Process	GO:0007369	gastrulation	IGI	J:132584
Biological Process	GO:0007507	heart development	IDA	J:47293
Biological Process	GO:0001701	in utero embryonic development	IMP	J:51595
Biological Process	GO:0001763	morphogenesis of a branching structure	IDA	J:113883
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	IGI	J:130239
Biological Process	GO:0038092	nodal signaling pathway	IMP	J:183227
Biological Process	GO:0038092	nodal signaling pathway	IGI	J:190004
Biological Process	GO:0030335	positive regulation of cell migration	IDA	J:113883
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:18846
Biological Process	GO:0001954	positive regulation of cell-matrix adhesion	IMP	J:51595
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	IMP	J:51595
Biological Process	GO:0043406	positive regulation of MAP kinase activity	ISO	J:38680
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:123041
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:123041
Biological Process	GO:0010762	regulation of fibroblast migration	IMP	J:51595
Biological Process	GO:0009966	regulation of signal transduction	IDA	J:127541
Biological Process	GO:0001570	vasculogenesis	IMP	J:51595