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GO Annotations Graph
Symbol
Name
ID
Ptgs2
prostaglandin-endoperoxide synthase 2
MGI:97798

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:0051213dioxygenase activityIEAJ:60000
Molecular FunctionGO:0019899enzyme bindingISOJ:164563
Molecular FunctionGO:0020037heme bindingIDAJ:182405
Molecular FunctionGO:0008289lipid bindingISOJ:155856
Molecular FunctionGO:0046872metal ion bindingIEAJ:60000
Molecular FunctionGO:0016491oxidoreductase activityIEAJ:60000
Molecular FunctionGO:0016702oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygenISOJ:155856
Molecular FunctionGO:0004601peroxidase activityIEAJ:72247
Molecular FunctionGO:0004601peroxidase activityIEAJ:60000
Molecular FunctionGO:0004666prostaglandin-endoperoxide synthase activityIDAJ:182405
Molecular FunctionGO:0004666prostaglandin-endoperoxide synthase activityIDAJ:3829
Molecular FunctionGO:0004666prostaglandin-endoperoxide synthase activityISOJ:164563
Molecular FunctionGO:0042803protein homodimerization activityIPIJ:182405
Cellular ComponentGO:0005901colocalizes_with
caveola
ISOJ:155856
Cellular ComponentGO:0005737cytoplasmISOJ:155856
Cellular ComponentGO:0005737cytoplasmISOJ:164563
Cellular ComponentGO:0005737cytoplasmIDAJ:77512
Cellular ComponentGO:0005783endoplasmic reticulumISOJ:164563
Cellular ComponentGO:0043231intracellular membrane-bounded organelleIEAJ:60000
Cellular ComponentGO:0016020membraneIEAJ:60000
Cellular ComponentGO:0043005neuron projectionIDAJ:79955
Cellular ComponentGO:0043005neuron projectionISOJ:79955
Cellular ComponentGO:0043234protein complexISOJ:155856
Biological ProcessGO:0042640anagenIMPJ:96826
Biological ProcessGO:0001525angiogenesisISOJ:155856
Biological ProcessGO:0030282bone mineralizationISOJ:137037
Biological ProcessGO:0050873brown fat cell differentiationIMPJ:160553
Biological ProcessGO:0071498cellular response to fluid shear stressIDAJ:216329
Biological ProcessGO:0019371cyclooxygenase pathwayIDAJ:3829
Biological ProcessGO:0019371cyclooxygenase pathwayISOJ:164563
Biological ProcessGO:0019371cyclooxygenase pathwayIDAJ:182405
Biological ProcessGO:0046697decidualizationISOJ:155856
Biological ProcessGO:0046697decidualizationIMPJ:56144
Biological ProcessGO:0007566embryo implantationISOJ:155856
Biological ProcessGO:0007566embryo implantationIMPJ:56144
Biological ProcessGO:0006633fatty acid biosynthetic processIEAJ:60000
Biological ProcessGO:0006631fatty acid metabolic processIEAJ:60000
Biological ProcessGO:0006954inflammatory responseISOJ:155856
Biological ProcessGO:0030216keratinocyte differentiationNASJ:77156
Biological ProcessGO:0007612learningISOJ:155856
Biological ProcessGO:0006629lipid metabolic processIEAJ:60000
Biological ProcessGO:0035633maintenance of blood-brain barrierISOJ:155856
Biological ProcessGO:0007613memoryISOJ:155856
Biological ProcessGO:0051926negative regulation of calcium ion transportISOJ:155856
Biological ProcessGO:0045786negative regulation of cell cycleISOJ:155856
Biological ProcessGO:0008285negative regulation of cell proliferationISOJ:155856
Biological ProcessGO:0045986negative regulation of smooth muscle contractionISOJ:155856
Biological ProcessGO:0032227negative regulation of synaptic transmission, dopaminergicISOJ:155856
Biological ProcessGO:0030728ovulationISOJ:155856
Biological ProcessGO:0055114oxidation-reduction processIEAJ:72247
Biological ProcessGO:0055114oxidation-reduction processIEAJ:60000
Biological ProcessGO:0043065positive regulation of apoptotic processISOJ:155856
Biological ProcessGO:0090336positive regulation of brown fat cell differentiationIMPJ:160553
Biological ProcessGO:0010942positive regulation of cell deathISOJ:155856
Biological ProcessGO:0090050positive regulation of cell migration involved in sprouting angiogenesisISOJ:155856
Biological ProcessGO:0008284positive regulation of cell proliferationISOJ:155856
Biological ProcessGO:0031622positive regulation of fever generationISOJ:155856
Biological ProcessGO:0031622positive regulation of fever generationIDAJ:155398
Biological ProcessGO:0090271positive regulation of fibroblast growth factor productionISOJ:155856
Biological ProcessGO:0042346positive regulation of NF-kappaB import into nucleusISOJ:155856
Biological ProcessGO:0045429positive regulation of nitric oxide biosynthetic processISOJ:155856
Biological ProcessGO:0090362positive regulation of platelet-derived growth factor productionISOJ:155856
Biological ProcessGO:0048661positive regulation of smooth muscle cell proliferationISOJ:155856
Biological ProcessGO:0045987positive regulation of smooth muscle contractionISOJ:155856
Biological ProcessGO:0031915positive regulation of synaptic plasticityISOJ:155856
Biological ProcessGO:0051968positive regulation of synaptic transmission, glutamatergicISOJ:155856
Biological ProcessGO:0071636positive regulation of transforming growth factor beta productionISOJ:155856
Biological ProcessGO:0010575positive regulation of vascular endothelial growth factor productionISOJ:155856
Biological ProcessGO:0045907positive regulation of vasoconstrictionISOJ:155856
Biological ProcessGO:0001516prostaglandin biosynthetic processISOJ:155856
Biological ProcessGO:0001516prostaglandin biosynthetic processIDAJ:182405
Biological ProcessGO:0006693prostaglandin metabolic processIEAJ:60000
Biological ProcessGO:0008217regulation of blood pressureIMPJ:77475
Biological ProcessGO:0042127regulation of cell proliferationIGIJ:64401
Biological ProcessGO:0042127regulation of cell proliferationIGIJ:68513
Biological ProcessGO:0042127regulation of cell proliferationIGIJ:36816
Biological ProcessGO:0042127regulation of cell proliferationIGIJ:61978
Biological ProcessGO:0042127regulation of cell proliferationIGIJ:74003
Biological ProcessGO:0034097response to cytokineISOJ:155856
Biological ProcessGO:0032496response to lipopolysaccharideISOJ:155856
Biological ProcessGO:0006979response to oxidative stressIEAJ:72247
Biological ProcessGO:0019233sensory perception of painISOJ:155856


Gene Ontology Evidence Code Abbreviations:

Experimental:
EXP
Inferred from experiment
HMP
Inferred from high throughput mutant phenotype
HGI
Inferred from high throughput genetic interaction
HDA
Inferred from high throughput direct assay
HEP
Inferred from high throughput expression pattern
IDA
Inferred from direct assay
IEP
Inferred from expression pattern
IGI
Inferred from genetic interaction
IMP
Inferred from mutant phenotype
IPI
Inferred from physical interaction
Homology:
IAS
Inferred from ancestral sequence
IBA
Inferred from biological aspect of ancestor
IBD
Inferred from biological aspect of descendant
IKR
Inferred from key residues
IMR
Inferred from missing residues
IRD
Inferred from rapid divergence
ISA
Inferred from sequence alignment
ISM
Inferred from sequence model
ISO
Inferred from sequence orthology
ISS
Inferred from sequence or structural similarity
Automated:
IEA
Inferred from electronic annotation
RCA
Reviewed computational analysis
Other:
IC
Inferred by curator
NAS
Non-traceable author statement
ND
No biological data available
TAS
Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory