GO Annotations Graph

• Symbol: Ptgs2
• Name: prostaglandin-endoperoxide synthase 2
• ID: MGI:97798

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051213	dioxygenase activity	IEA	J:60000
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0020037	heme binding	IDA	J:182405
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	ISO	J:155856
Molecular Function	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IBA	J:265628
Molecular Function	GO:0004601	peroxidase activity	IEA	J:60000
Molecular Function	GO:0004601	peroxidase activity	IEA	J:72247
Molecular Function	GO:0004666	prostaglandin-endoperoxide synthase activity	ISO	J:164563
Molecular Function	GO:0004666	prostaglandin-endoperoxide synthase activity	IDA	J:182405
Molecular Function	GO:0004666	prostaglandin-endoperoxide synthase activity	IBA	J:265628
Molecular Function	GO:0004666	prostaglandin-endoperoxide synthase activity	IDA	J:3829
Molecular Function	GO:0005515	protein binding	IPI	J:139023
Molecular Function	GO:0042803	protein homodimerization activity	IPI	J:182405
Cellular Component	GO:0005901	caveola	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IMP	J:194718
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:77512
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0043005	neuron projection	IBA	J:265628
Cellular Component	GO:0043005	neuron projection	IDA	J:79955
Cellular Component	GO:0043005	neuron projection	ISO	J:79955
Cellular Component	GO:0005637	nuclear inner membrane	IDA	J:285003
Cellular Component	GO:0005637	nuclear inner membrane	ISO	J:164563
Cellular Component	GO:0005640	nuclear outer membrane	IDA	J:285003
Cellular Component	GO:0005640	nuclear outer membrane	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Biological Process	GO:0042640	anagen	IMP	J:96826
Biological Process	GO:0001525	angiogenesis	ISO	J:155856
Biological Process	GO:0030282	bone mineralization	ISO	J:137037
Biological Process	GO:0050873	brown fat cell differentiation	IMP	J:160553
Biological Process	GO:0071498	cellular response to fluid shear stress	IDA	J:216329
Biological Process	GO:0071471	cellular response to non-ionic osmotic stress	IMP	J:194718
Biological Process	GO:0019371	cyclooxygenase pathway	ISO	J:164563
Biological Process	GO:0019371	cyclooxygenase pathway	IDA	J:182405
Biological Process	GO:0019371	cyclooxygenase pathway	IBA	J:265628
Biological Process	GO:0019371	cyclooxygenase pathway	IDA	J:3829
Biological Process	GO:0046697	decidualization	ISO	J:155856
Biological Process	GO:0046697	decidualization	IMP	J:56144
Biological Process	GO:0007566	embryo implantation	ISO	J:155856
Biological Process	GO:0007566	embryo implantation	IMP	J:56144
Biological Process	GO:0006633	fatty acid biosynthetic process	IEA	J:60000
Biological Process	GO:0006631	fatty acid metabolic process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	ISO	J:155856
Biological Process	GO:0030216	keratinocyte differentiation	NAS	J:77156
Biological Process	GO:0007612	learning	ISO	J:155856
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0035633	maintenance of blood-brain barrier	ISO	J:155856
Biological Process	GO:0007613	memory	ISO	J:155856
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:194718
Biological Process	GO:0051926	negative regulation of calcium ion transport	ISO	J:155856
Biological Process	GO:0045786	negative regulation of cell cycle	ISO	J:155856
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP	J:194718
Biological Process	GO:1902219	negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress	IMP	J:194718
Biological Process	GO:0045986	negative regulation of smooth muscle contraction	ISO	J:155856
Biological Process	GO:0032227	negative regulation of synaptic transmission, dopaminergic	ISO	J:155856
Biological Process	GO:0030728	ovulation	ISO	J:155856
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0090336	positive regulation of brown fat cell differentiation	IMP	J:160553
Biological Process	GO:0010942	positive regulation of cell death	ISO	J:155856
Biological Process	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0031622	positive regulation of fever generation	IDA	J:155398
Biological Process	GO:0031622	positive regulation of fever generation	ISO	J:155856
Biological Process	GO:0090271	positive regulation of fibroblast growth factor production	ISO	J:155856
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	ISO	J:155856
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	IMP	J:194718
Biological Process	GO:0090362	positive regulation of platelet-derived growth factor production	ISO	J:155856
Biological Process	GO:0031394	positive regulation of prostaglandin biosynthetic process	IMP	J:194718
Biological Process	GO:0042307	positive regulation of protein import into nucleus	ISO	J:155856
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0045987	positive regulation of smooth muscle contraction	ISO	J:155856
Biological Process	GO:0031915	positive regulation of synaptic plasticity	ISO	J:155856
Biological Process	GO:0051968	positive regulation of synaptic transmission, glutamatergic	ISO	J:155856
Biological Process	GO:0071636	positive regulation of transforming growth factor beta production	ISO	J:155856
Biological Process	GO:0010575	positive regulation of vascular endothelial growth factor production	ISO	J:155856
Biological Process	GO:0045907	positive regulation of vasoconstriction	ISO	J:155856
Biological Process	GO:0001516	prostaglandin biosynthetic process	ISO	J:155856
Biological Process	GO:0001516	prostaglandin biosynthetic process	IDA	J:182405
Biological Process	GO:0001516	prostaglandin biosynthetic process	ISO	J:164563
Biological Process	GO:0006693	prostaglandin metabolic process	IEA	J:60000
Biological Process	GO:0032310	prostaglandin secretion	IMP	J:301363
Biological Process	GO:0008217	regulation of blood pressure	IMP	J:77475
Biological Process	GO:0042127	regulation of cell population proliferation	IGI	J:68513
Biological Process	GO:0042127	regulation of cell population proliferation	IGI	J:64401
Biological Process	GO:0042127	regulation of cell population proliferation	IGI	J:74003
Biological Process	GO:0042127	regulation of cell population proliferation	IGI	J:36816
Biological Process	GO:0042127	regulation of cell population proliferation	IGI	J:61978
Biological Process	GO:0042127	regulation of cell population proliferation	IGI	J:74003
Biological Process	GO:0150077	regulation of neuroinflammatory response	IDA	J:261928
Biological Process	GO:0034097	response to cytokine	ISO	J:155856
Biological Process	GO:0032496	response to lipopolysaccharide	ISO	J:155856
Biological Process	GO:0009624	response to nematode	IMP	J:301363
Biological Process	GO:0006979	response to oxidative stress	IEA	J:72247
Biological Process	GO:0019233	sensory perception of pain	ISO	J:155856