GO Annotations Graph

• Symbol: Ptger3
• Name: prostaglandin E receptor 3 (subtype EP3)
• ID: MGI:97795

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:60000
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:72247
Molecular Function	GO:0004957	prostaglandin E receptor activity	ISO	J:155856
Molecular Function	GO:0004957	prostaglandin E receptor activity	IBA	J:265628
Molecular Function	GO:0004957	prostaglandin E receptor activity	IDA	J:15691
Molecular Function	GO:0004957	prostaglandin E receptor activity	IMP	J:26652
Molecular Function	GO:0004957	prostaglandin E receptor activity	IDA	J:20413
Molecular Function	GO:0004957	prostaglandin E receptor activity	IDA	J:20967
Molecular Function	GO:0004955	prostaglandin receptor activity	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:20413
Cellular Component	GO:0031526	brush border membrane	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0031965	nuclear membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IDA	J:15691
Cellular Component	GO:0005886	plasma membrane	IDA	J:15973
Cellular Component	GO:1990769	proximal neuron projection	ISO	J:155856
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IDA	J:15691
Biological Process	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IDA	J:15973
Biological Process	GO:0015701	bicarbonate transport	IMP	J:59696
Biological Process	GO:1904322	cellular response to forskolin	ISO	J:155856
Biological Process	GO:0002029	desensitization of G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0001660	fever generation	IDA	J:70534
Biological Process	GO:0001660	fever generation	IMP	J:70534
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IDA	J:20967
Biological Process	GO:0006954	inflammatory response	IBA	J:265628
Biological Process	GO:0014827	intestine smooth muscle contraction	ISO	J:155856
Biological Process	GO:0014827	intestine smooth muscle contraction	IBA	J:265628
Biological Process	GO:0106072	negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:1903170	negative regulation of calcium ion transmembrane transport	ISO	J:155856
Biological Process	GO:1904326	negative regulation of circadian sleep/wake cycle, wakefulness	ISO	J:155856
Biological Process	GO:2000978	negative regulation of forebrain neuron differentiation	ISO	J:155856
Biological Process	GO:0060455	negative regulation of gastric acid secretion	ISO	J:155856
Biological Process	GO:0060455	negative regulation of gastric acid secretion	IBA	J:265628
Biological Process	GO:1903640	negative regulation of gastrin-induced gastric acid secretion	ISO	J:155856
Biological Process	GO:0046676	negative regulation of insulin secretion	ISO	J:155856
Biological Process	GO:0010700	negative regulation of norepinephrine secretion	ISO	J:155856
Biological Process	GO:0090331	negative regulation of platelet aggregation	ISO	J:155856
Biological Process	GO:1901380	negative regulation of potassium ion transmembrane transport	ISO	J:155856
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	IDA	J:20967
Biological Process	GO:0043950	positive regulation of cAMP-mediated signaling	ISO	J:155856
Biological Process	GO:0046010	positive regulation of circadian sleep/wake cycle, non-REM sleep	ISO	J:155856
Biological Process	GO:1904343	positive regulation of colon smooth muscle contraction	ISO	J:155856
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	IBA	J:265628
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	IDA	J:20967
Biological Process	GO:0031622	positive regulation of fever generation	IMP	J:155398
Biological Process	GO:1904346	positive regulation of gastric mucosal blood circulation	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:1904325	positive regulation of inhibitory G protein-coupled receptor phosphorylation	ISO	J:155856
Biological Process	GO:1904330	positive regulation of myofibroblast contraction	ISO	J:155856
Biological Process	GO:2000391	positive regulation of neutrophil extravasation	ISO	J:155856
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:1904320	positive regulation of smooth muscle contraction involved in micturition	ISO	J:155856
Biological Process	GO:0035810	positive regulation of urine volume	IMP	J:52323
Biological Process	GO:0045907	positive regulation of vasoconstriction	ISO	J:155856
Biological Process	GO:1990767	prostaglandin receptor internalization	ISO	J:155856
Biological Process	GO:0031623	receptor internalization	ISO	J:155856
Biological Process	GO:0010840	regulation of circadian sleep/wake cycle, wakefulness	ISO	J:155856
Biological Process	GO:0014061	regulation of norepinephrine secretion	ISO	J:155856
Biological Process	GO:0032496	response to lipopolysaccharide	IMP	J:98317
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:0014832	urinary bladder smooth muscle contraction	ISO	J:155856