Plcg2 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Plcg2
phospholipase C, gamma 2
MGI:97616

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0034480	phosphatidylcholine phospholipase C activity	TAS	Reactome:R-MMU-9682158
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	ISO	J:155856
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	ISO	J:164563
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	EXP	J:266152
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	IBA	J:265628
Molecular Function	GO:0004629	phospholipase C activity	TAS	J:75316
Molecular Function	GO:0008081	phosphoric diester hydrolase activity	IEA	J:72247
Molecular Function	GO:0140031	phosphorylation-dependent protein binding	IPI	J:76319
Molecular Function	GO:0001784	phosphotyrosine residue binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0005515	protein binding	IPI	J:200363
Molecular Function	GO:0005515	protein binding	IPI	J:232061
Molecular Function	GO:0005515	protein binding	IPI	J:114724
Molecular Function	GO:0005515	protein binding	IPI	J:237276
Molecular Function	GO:0005515	protein binding	IPI	J:237276
Molecular Function	GO:0005515	protein binding	IPI	J:129312
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:1990782	protein tyrosine kinase binding	ISO	J:164563
Molecular Function	GO:0097110	scaffold protein binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IMP	J:63744
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-5607754
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9027429
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9027436
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9032476
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9680646
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9682158
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9682182
Cellular Component	GO:0097708	intracellular vesicle	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0032587	ruffle membrane	ISO	J:164563
Biological Process	GO:0032237	activation of store-operated calcium channel activity	IMP	J:95865
Biological Process	GO:0061760	antifungal innate immune response	IMP	J:178744
Biological Process	GO:0030183	B cell differentiation	IMP	J:63744
Biological Process	GO:0050853	B cell receptor signaling pathway	ISO	J:164563
Biological Process	GO:0050853	B cell receptor signaling pathway	IMP	J:63744
Biological Process	GO:0019722	calcium-mediated signaling	ISO	J:164563
Biological Process	GO:0001775	cell activation	IMP	J:148372
Biological Process	GO:0071277	cellular response to calcium ion	ISO	J:164563
Biological Process	GO:1990858	cellular response to lectin	IMP	J:148372
Biological Process	GO:0071396	cellular response to lipid	ISO	J:164563
Biological Process	GO:0002316	follicular B cell differentiation	IMP	J:86373
Biological Process	GO:0032959	inositol trisphosphate biosynthetic process	IDA	J:38367
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:164563
Biological Process	GO:0035556	intracellular signal transduction	IMP	J:148372
Biological Process	GO:0035556	intracellular signal transduction	IMP	J:178744
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:155856
Biological Process	GO:0016042	lipid catabolic process	IEA	J:60000
Biological Process	GO:0006629	lipid metabolic process	IEA	J:72247
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0002281	macrophage activation involved in immune response	IMP	J:178744
Biological Process	GO:0043069	negative regulation of programmed cell death	IMP	J:86373
Biological Process	GO:0006661	phosphatidylinositol biosynthetic process	ISO	J:164563
Biological Process	GO:0048015	phosphatidylinositol-mediated signaling	IBA	J:265628
Biological Process	GO:0009395	phospholipid catabolic process	IEA	J:72247
Biological Process	GO:0050850	positive regulation of calcium-mediated signaling	IMP	J:148372
Biological Process	GO:1902808	positive regulation of cell cycle G1/S phase transition	ISO	J:155856
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:0002732	positive regulation of dendritic cell cytokine production	IMP	J:148372
Biological Process	GO:0002732	positive regulation of dendritic cell cytokine production	IMP	J:148372
Biological Process	GO:0002732	positive regulation of dendritic cell cytokine production	IMP	J:148372
Biological Process	GO:0002732	positive regulation of dendritic cell cytokine production	IMP	J:148372
Biological Process	GO:0002732	positive regulation of dendritic cell cytokine production	IMP	J:148372
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ISO	J:155856
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	IMP	J:148372
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	IMP	J:148372
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	IMP	J:148372
Biological Process	GO:0010634	positive regulation of epithelial cell migration	IBA	J:265628
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:1903721	positive regulation of I-kappaB phosphorylation	IMP	J:178744
Biological Process	GO:0032733	positive regulation of interleukin-10 production	IMP	J:178744
Biological Process	GO:0032733	positive regulation of interleukin-10 production	IMP	J:148372
Biological Process	GO:0032735	positive regulation of interleukin-12 production	IMP	J:178744
Biological Process	GO:0032743	positive regulation of interleukin-2 production	IMP	J:148372
Biological Process	GO:0032747	positive regulation of interleukin-23 production	IMP	J:148372
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IMP	J:178744
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IMP	J:148372
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:178744
Biological Process	GO:0043410	positive regulation of MAPK cascade	IMP	J:178744
Biological Process	GO:0043410	positive regulation of MAPK cascade	IMP	J:148372
Biological Process	GO:0150078	positive regulation of neuroinflammatory response	ISO	J:164563
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IMP	J:148372
Biological Process	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly	ISO	J:164563
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IMP	J:178744
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IMP	J:178744
Biological Process	GO:0060100	positive regulation of phagocytosis, engulfment	ISO	J:164563
Biological Process	GO:1903428	positive regulation of reactive oxygen species biosynthetic process	IMP	J:178744
Biological Process	GO:0002092	positive regulation of receptor internalization	IMP	J:178826
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IMP	J:148372
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IMP	J:178744
Biological Process	GO:0032481	positive regulation of type I interferon production	IMP	J:178826
Biological Process	GO:0012501	programmed cell death	IMP	J:86373
Biological Process	GO:0070884	regulation of calcineurin-NFAT signaling cascade	IMP	J:148372
Biological Process	GO:0010468	regulation of gene expression	IMP	J:86373
Biological Process	GO:0010468	regulation of gene expression	IMP	J:86373
Biological Process	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	IMP	J:178744
Biological Process	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	IMP	J:148372
Biological Process	GO:0019216	regulation of lipid metabolic process	ISO	J:164563
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	IMP	J:63744
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	ISO	J:164563
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	IBA	J:265628
Biological Process	GO:0033198	response to ATP	ISO	J:155856
Biological Process	GO:0048678	response to axon injury	ISO	J:164563
Biological Process	GO:0032496	response to lipopolysaccharide	IDA	J:38367
Biological Process	GO:0032026	response to magnesium ion	ISO	J:155856
Biological Process	GO:0001878	response to yeast	IMP	J:178744
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:0002223	stimulatory C-type lectin receptor signaling pathway	IMP	J:178744
Biological Process	GO:0002223	stimulatory C-type lectin receptor signaling pathway	IMP	J:148372
Biological Process	GO:0050852	T cell receptor signaling pathway	IDA	J:96628
Biological Process	GO:0002224	toll-like receptor signaling pathway	IMP	J:148372

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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