Plcb1 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Plcb1
phospholipase C, beta 1
MGI:97613

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005246	calcium channel regulator activity	IDA	J:169993
Molecular Function	GO:0005509	calcium ion binding	ISO	J:155856
Molecular Function	GO:0005516	calmodulin binding	ISO	J:164563
Molecular Function	GO:0005516	calmodulin binding	IBA	J:265628
Molecular Function	GO:0099103	channel activator activity	IDA	J:169993
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0005096	GTPase activator activity	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0099107	ion channel regulator activity involved in G protein-coupled receptor signaling pathway	IDA	J:169993
Molecular Function	GO:0005521	lamin binding	IPI	J:169987
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	ISO	J:155856
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	ISO	J:164563
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	IBA	J:265628
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	IDA	J:169993
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	IDA	J:169993
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	IDA	J:169993
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	IDA	J:169993
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	ISO	J:164563
Molecular Function	GO:0008081	phosphoric diester hydrolase activity	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:169991
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	IDA	J:169993
Cellular Component	GO:0000785	chromatin	IDA	J:169987
Cellular Component	GO:0005737	cytoplasm	IDA	J:169907
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:169990
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	ISO	J:117528
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0098982	GABA-ergic synapse	IDA	J:124819
Cellular Component	GO:0098982	GABA-ergic synapse	IMP	J:124819
Cellular Component	GO:0098982	GABA-ergic synapse	IDA	J:124819
Cellular Component	GO:0098978	glutamatergic synapse	EXP	J:103748
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:103748
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:103748
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0043209	myelin sheath	HDA	J:145263
Cellular Component	GO:0016607	nuclear speck	IDA	J:169991
Cellular Component	GO:0016607	nuclear speck	ISO	J:164563
Cellular Component	GO:0016607	nuclear speck	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:169790
Cellular Component	GO:0005634	nucleus	IDA	J:169809
Cellular Component	GO:0005634	nucleus	NAS	J:169993
Cellular Component	GO:0005634	nucleus	IDA	J:169907
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:169990
Cellular Component	GO:0005634	nucleus	IDA	J:169795
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-445860
Cellular Component	GO:0005886	plasma membrane	ISO	J:328022
Cellular Component	GO:0005886	plasma membrane	ISO	J:328022
Cellular Component	GO:0098794	postsynapse	IDA	J:103748
Cellular Component	GO:0099524	postsynaptic cytosol	IDA	J:143242
Cellular Component	GO:0099524	postsynaptic cytosol	IEP	J:143242
Cellular Component	GO:0099524	postsynaptic cytosol	IDA	J:143242
Cellular Component	GO:0099524	postsynaptic cytosol	IDA	J:143242
Cellular Component	GO:0032991	protein-containing complex	IDA	J:240063
Biological Process	GO:0060466	activation of meiosis involved in egg activation	IDA	J:169795
Biological Process	GO:0007420	brain development	NAS	J:169989
Biological Process	GO:0007155	cell adhesion	IC	J:169907
Biological Process	GO:1902618	cellular response to fluoride	ISO	J:155856
Biological Process	GO:1905631	cellular response to glyceraldehyde	ISO	J:155856
Biological Process	GO:1904637	cellular response to ionomycin	ISO	J:155856
Biological Process	GO:1904117	cellular response to vasopressin	ISO	J:155856
Biological Process	GO:0021987	cerebral cortex development	IMP	J:109291
Biological Process	GO:0030218	erythrocyte differentiation	TAS	J:169984
Biological Process	GO:0045444	fat cell differentiation	IDA	J:169980
Biological Process	GO:0007213	G protein-coupled acetylcholine receptor signaling pathway	IMP	J:43077
Biological Process	GO:0000086	G2/M transition of mitotic cell cycle	IDA	J:169987
Biological Process	GO:0000086	G2/M transition of mitotic cell cycle	NAS	J:169990
Biological Process	GO:0007215	glutamate receptor signaling pathway	IMP	J:109291
Biological Process	GO:0032957	inositol trisphosphate metabolic process	ISO	J:155856
Biological Process	GO:0008286	insulin receptor signaling pathway	TAS	J:169984
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IDA	J:169815
Biological Process	GO:0070498	interleukin-1-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0035722	interleukin-12-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0035723	interleukin-15-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0035556	intracellular signal transduction	IEA	J:72247
Biological Process	GO:0099105	ion channel modulating, G protein-coupled receptor signaling pathway	IMP	J:289428
Biological Process	GO:0099105	ion channel modulating, G protein-coupled receptor signaling pathway	IMP	J:289428
Biological Process	GO:0099105	ion channel modulating, G protein-coupled receptor signaling pathway	IMP	J:232958
Biological Process	GO:1990806	ligand-gated ion channel signaling pathway	IMP	J:289428
Biological Process	GO:1990806	ligand-gated ion channel signaling pathway	IMP	J:289428
Biological Process	GO:1990806	ligand-gated ion channel signaling pathway	IMP	J:232958
Biological Process	GO:0016042	lipid catabolic process	IEA	J:72247
Biological Process	GO:0016042	lipid catabolic process	IEA	J:60000
Biological Process	GO:0006629	lipid metabolic process	IEA	J:72247
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0030225	macrophage differentiation	NAS	J:155351
Biological Process	GO:0007613	memory	IMP	J:169989
Biological Process	GO:0007613	memory	IBA	J:265628
Biological Process	GO:0006397	mRNA processing	TAS	J:170753
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:169803
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:169991
Biological Process	GO:2000438	negative regulation of monocyte extravasation	IDA	J:167110
Biological Process	GO:0001556	oocyte maturation	NAS	J:169990
Biological Process	GO:0031161	phosphatidylinositol catabolic process	ISO	J:155856
Biological Process	GO:0046488	phosphatidylinositol metabolic process	ISO	J:164563
Biological Process	GO:0048015	phosphatidylinositol-mediated signaling	IBA	J:265628
Biological Process	GO:0007207	phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	IMP	J:289428
Biological Process	GO:0007207	phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	IGI	J:58572
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	IMP	J:289428
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	IMP	J:232958
Biological Process	GO:2000344	positive regulation of acrosome reaction	IMP	J:70264
Biological Process	GO:2000560	positive regulation of CD24 production	IDA	J:169907
Biological Process	GO:0048639	positive regulation of developmental growth	IMP	J:93076
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:169907
Biological Process	GO:0040019	positive regulation of embryonic development	IMP	J:70264
Biological Process	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	IDA	J:169809
Biological Process	GO:0032024	positive regulation of insulin secretion	IMP	J:289428
Biological Process	GO:0032024	positive regulation of insulin secretion	IMP	J:289428
Biological Process	GO:0032024	positive regulation of insulin secretion	IGI	J:58572
Biological Process	GO:0032024	positive regulation of insulin secretion	IMP	J:232958
Biological Process	GO:0032735	positive regulation of interleukin-12 production	IMP	J:169995
Biological Process	GO:0046330	positive regulation of JNK cascade	ISO	J:164563
Biological Process	GO:0045663	positive regulation of myoblast differentiation	IDA	J:169790
Biological Process	GO:0032417	positive regulation of sodium:proton antiporter activity	NAS	J:169906
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	IDA	J:103748
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	IMP	J:103748
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	EXP	J:103748
Biological Process	GO:0051726	regulation of cell cycle	IEA	J:72247
Biological Process	GO:1903140	regulation of establishment of endothelial barrier	IMP	J:242176
Biological Process	GO:0080154	regulation of fertilization	IMP	J:70264
Biological Process	GO:0008277	regulation of G protein-coupled receptor signaling pathway	IMP	J:169989
Biological Process	GO:0099178	regulation of retrograde trans-synaptic signaling by endocanabinoid	IDA	J:124819
Biological Process	GO:0099178	regulation of retrograde trans-synaptic signaling by endocanabinoid	IMP	J:124819
Biological Process	GO:0099178	regulation of retrograde trans-synaptic signaling by endocanabinoid	IDA	J:124819
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	IBA	J:265628
Biological Process	GO:0034284	response to monosaccharide	ISO	J:155856
Biological Process	GO:0043434	response to peptide hormone	ISO	J:155856
Biological Process	GO:0007165	signal transduction	TAS	J:169984

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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